Literature DB >> 26252859

One-Pot Catalytic Asymmetric Synthesis of Tetrahydrocarbazoles.

Qiong-Jie Liu1, Wen-Guang Yan1, Lijia Wang1, X Peter Zhang2, Yong Tang1.   

Abstract

A one-pot asymmetric synthesis of 1,2,3,4-tetrahydrocarbazoles has been developed via an enantioselective [3 + 3] annulation of 2-alkynylindoles and donor-acceptor cyclopropanes. In the presence of chiral Lewis acids as catalysts, a series of optically active tetrahydrocarbazoles were furnished in high yields (63-87%) with good to excellent levels of enantioselectivity (up to 94% ee).

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Year:  2015        PMID： 26252859      PMCID： PMC4746102          DOI： 10.1021/acs.orglett.5b01909

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  67 in total

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