| Literature DB >> 17664321 |
Costas C Papagiannitsis1, Leonidas S Tzouvelekis, Eva Tzelepi, Vivi Miriagou.
Abstract
ACC-4, an omega loop mutant (Val(211)-->Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla(ACC-4) shared similarities with plasmidic regions carrying bla(ACC-1). Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins.Entities:
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Year: 2007 PMID: 17664321 PMCID: PMC2043296 DOI: 10.1128/AAC.00389-07
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191