Literature DB >> 19470510

Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.

Stathis D Kotsakis1, Costas C Papagiannitsis, Eva Tzelepi, Leonidas S Tzouvelekis, Vivi Miriagou.   

Abstract

CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase, was derived by mutagenesis. The hydrolytic efficiency of CMY-30 against expanded-spectrum cephalosporins was higher than that of CMY-2 due to increased k(cat) values. Findings indicate a role of the Omega loop residue 211 in determining the substrate specificities of CMYs also corroborated by modeling studies.

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Year:  2009        PMID： 19470510      PMCID： PMC2715598          DOI： 10.1128/AAC.00219-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Plasmid-determined AmpC-type beta-lactamases.

Authors:  Alain Philippon; Guillaume Arlet; George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

2.  Experimental prediction of the evolution of cefepime resistance from the CMY-2 AmpC beta-lactamase.

Authors:  Miriam Barlow; Barry G Hall
Journal:  Genetics       Date:  2003-05       Impact factor: 4.562

3.  CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.

Authors:  Christopher E Pope; Philip E Carter; Helen M Heffernan
Journal:  Antimicrob Agents Chemother       Date:  2009-05-04       Impact factor: 5.191

4.  Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.

Authors:  R A Powers; E Caselli; P J Focia; F Prati; B K Shoichet
Journal:  Biochemistry       Date:  2001-08-07       Impact factor: 3.162

5.  Regulation of enterobacterial cephalosporinase production: the role of a membrane-bound sensory transducer.

Authors:  N Honoré; M H Nicolas; S T Cole
Journal:  Mol Microbiol       Date:  1989-08       Impact factor: 3.501

6.  A survey of the kinetic parameters of class C beta-lactamases. Cephalosporins and other beta-lactam compounds.

Authors:  M Galleni; G Amicosante; J M Frère
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

7.  Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes.

Authors:  Michiyoshi Nukaga; Sanjai Kumar; Kayoko Nukaga; R F Pratt; James R Knox
Journal:  J Biol Chem       Date:  2003-12-03       Impact factor: 5.157

8.  Molecular evolution of a class C beta-lactamase extending its substrate specificity.

Authors:  M Nukaga; S Haruta; K Tanimoto; K Kogure; K Taniguchi; M Tamaki; T Sawai
Journal:  J Biol Chem       Date:  1995-03-17       Impact factor: 5.157

9.  Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams.

Authors:  H Vu; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

10.  The effect of amino acid substitution at position 219 of Citrobacter freundii cephalosporinase on extension of its substrate spectrum.

Authors:  K Tsukamoto; R Ohno; M Nukaga; T Sawai
Journal:  Eur J Biochem       Date:  1992-08-01
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  8 in total

1.  Identification of CMY-2-type cephalosporinases in clinical isolates of Enterobacteriaceae by MALDI-TOF MS.

Authors:  C C Papagiannitsis; S D Kotsakis; Z Tuma; M Gniadkowski; V Miriagou; J Hrabak
Journal:  Antimicrob Agents Chemother       Date:  2014-02-24       Impact factor: 5.191

2.  N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam.

Authors:  Marion J Skalweit; Mei Li; Benjamin C Conklin; Magdalena A Taracila; Rebecca A Hutton
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191

3.  Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli.

Authors:  S D Kotsakis; V Miriagou; E E Vetouli; E Bozavoutoglou; E Lebessi; E Tzelepi; L S Tzouvelekis
Journal:  Antimicrob Agents Chemother       Date:  2015-10-05       Impact factor: 5.191

Review 4.  Class C β-Lactamases: Molecular Characteristics.

Authors:  Alain Philippon; Guillaume Arlet; Roger Labia; Bogdan I Iorga
Journal:  Clin Microbiol Rev       Date:  2022-04-18       Impact factor: 50.129

5.  Interactions of oximino-substituted boronic acids and β-lactams with the CMY-2-derived extended-spectrum cephalosporinases CMY-30 and CMY-42.

Authors:  Stathis D Kotsakis; Emilia Caselli; Leonidas S Tzouvelekis; Efi Petinaki; Fabio Prati; Vivi Miriagou
Journal:  Antimicrob Agents Chemother       Date:  2012-12-10       Impact factor: 5.191

6.  Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor.

Authors:  Stathis D Kotsakis; Georgios Miliotis; Eva Tzelepi; Leonidas S Tzouvelekis; Vivi Miriagou
Journal:  Sci Rep       Date:  2021-06-08       Impact factor: 4.379

7.  New Delhi Metallo-β-Lactamase-Producing Enterobacterales Bacteria, Switzerland, 2019-2020.

Authors:  Jacqueline Findlay; Laurent Poirel; Julie Kessler; Andreas Kronenberg; Patrice Nordmann
Journal:  Emerg Infect Dis       Date:  2021-10       Impact factor: 6.883

8.  Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria.

Authors:  Stathis D Kotsakis; Anastasia Lambropoulou; Georgios Miliotis; Eva Tzelepi; Vivi Miriagou; Leonidas S Tzouvelekis
Journal:  Microbiol Spectr       Date:  2022-07-19
  8 in total

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