OBJECTIVES: To assess if prostate-specific antigen (PSA) nadir is an independent predictor of treatment failure and disease-free survival after high-intensity focussed ultrasound (HIFU) therapy for localised prostate cancer as defined by the new ASTRO criteria. METHODS: One hundred three patients after HIFU treatment (Ablatherm, EDAP, Lyon, France) for localised prostate cancer without previous hormonal therapy were evaluated retrospectively. Patients attended regular follow-up visits every 3 mo. Treatment failure was defined by the revised ASTRO criteria (PSA >or=2 ng/ml above nadir PSA, positive biopsy, if salvage treatment was administered). Patients were divided into three PSA nadir subgroups (group 1, <or=0.2 ng/ml; group 2, 0.21-1 ng/ml; group 3, >1 ng/ml). The disease-free survival rate (DFSR) was calculated by using life table methods. The log-rank test was used to compare the curves based on Kaplan-Meier models. RESULTS: The median follow-up was 4.9 (3-8.6) yr. Mean time to PSA nadir was 6.4+/-5.1 mo. A PSA nadir of <or=0.2 ng/ml, 0.21-1 ng/ml, and >1ng/ml was reached by 64%, 22.3%, and 13.6% of patients, respectively. Treatment failure rates during follow-up were 4.5%, 30.4%, and 100%, respectively, for the three groups (p<0.001). The actuarial DFSRs at 5 yr were 95%, 55%, and 0%, respectively, for the 3 groups (p<0.001). CONCLUSIONS: The PSA nadir after HIFU correlates highly significantly with treatment failure and DFSR, and can be applied in daily clinical practice. Promising oncological outcome is obtained if a PSA nadir of <or=0.2 ng/ml is reached.
OBJECTIVES: To assess if prostate-specific antigen (PSA) nadir is an independent predictor of treatment failure and disease-free survival after high-intensity focussed ultrasound (HIFU) therapy for localised prostate cancer as defined by the new ASTRO criteria. METHODS: One hundred three patients after HIFU treatment (Ablatherm, EDAP, Lyon, France) for localised prostate cancer without previous hormonal therapy were evaluated retrospectively. Patients attended regular follow-up visits every 3 mo. Treatment failure was defined by the revised ASTRO criteria (PSA >or=2 ng/ml above nadir PSA, positive biopsy, if salvage treatment was administered). Patients were divided into three PSA nadir subgroups (group 1, <or=0.2 ng/ml; group 2, 0.21-1 ng/ml; group 3, >1 ng/ml). The disease-free survival rate (DFSR) was calculated by using life table methods. The log-rank test was used to compare the curves based on Kaplan-Meier models. RESULTS: The median follow-up was 4.9 (3-8.6) yr. Mean time to PSA nadir was 6.4+/-5.1 mo. A PSA nadir of <or=0.2 ng/ml, 0.21-1 ng/ml, and >1ng/ml was reached by 64%, 22.3%, and 13.6% of patients, respectively. Treatment failure rates during follow-up were 4.5%, 30.4%, and 100%, respectively, for the three groups (p<0.001). The actuarial DFSRs at 5 yr were 95%, 55%, and 0%, respectively, for the 3 groups (p<0.001). CONCLUSIONS: The PSA nadir after HIFU correlates highly significantly with treatment failure and DFSR, and can be applied in daily clinical practice. Promising oncological outcome is obtained if a PSA nadir of <or=0.2 ng/ml is reached.
Authors: Thomas Ripert; Younes Bayoud; Rabah Messaoudi; Johann Ménard; Marie-Dominique Azémar; François Duval; Tan Dat Nguyen; Frédéric Staerman Journal: Can Urol Assoc J Date: 2011-05-01 Impact factor: 1.862
Authors: Himu Lukka; Tricia Waldron; Joseph Chin; Linda Mayhew; Padraig Warde; Eric Winquist; George Rodrigues; Bobby Shayegan Journal: Can Urol Assoc J Date: 2010-08 Impact factor: 1.862
Authors: Vincent Misraï; Morgan Rouprêt; Emmanuel Chartier-Kastler; Eva Comperat; Raphaële Renard-Penna; Alain Haertig; Marc-Olivier Bitker; François Richard; Pierre Conort Journal: World J Urol Date: 2008-06-26 Impact factor: 4.226
Authors: H U Ahmed; E Zacharakis; T Dudderidge; J N Armitage; R Scott; J Calleary; R Illing; A Kirkham; A Freeman; C Ogden; C Allen; M Emberton Journal: Br J Cancer Date: 2009-06-09 Impact factor: 7.640