Literature DB >> 17656311

Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology.

Vincenzo Di Marzo1, Tiziana Bisogno, Luciano De Petrocellis.   

Abstract

Cannabis sativa has been known, used, and misused by mankind for centuries, and yet only over the last two decades has research stemming from the chemical constituents specific to this plant, the cannabinoids, started to provide fundamental insights into animal physiology and pathology, resulting in the development of new therapeutics. The discovery of the endocannabinoid system, and its targeting with two new pharmaceutical preparations now on the market in several countries, represent the most recent example of how studies on medicinal plants and on the mechanism of their biological effects can reveal, through a chain of breakthroughs, new systems of endogenous signals and physiological phenomena that can become the source of novel strategies for unmet therapeutic challenges.

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Year:  2007        PMID: 17656311     DOI: 10.1016/j.chembiol.2007.05.014

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  44 in total

Review 1.  Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain.

Authors:  Bernard P Roques; Marie-Claude Fournié-Zaluski; Michel Wurm
Journal:  Nat Rev Drug Discov       Date:  2012-04       Impact factor: 84.694

2.  Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

Authors:  Susanna M Saario; Michele K McKinney; Anna E Speers; Chu Wang; Benjamin F Cravatt
Journal:  Chem Sci       Date:  2011-08-11       Impact factor: 9.825

3.  The endocannabinoid system in rat gliosomes and its role in the modulation of glutamate release.

Authors:  Monica Bari; Tiziana Bonifacino; Marco Milanese; Paola Spagnuolo; Simona Zappettini; Natalia Battista; Francesco Giribaldi; Cesare Usai; Giambattista Bonanno; Mauro Maccarrone
Journal:  Cell Mol Life Sci       Date:  2010-08-15       Impact factor: 9.261

Review 4.  The complications of promiscuity: endocannabinoid action and metabolism.

Authors:  S P H Alexander; D A Kendall
Journal:  Br J Pharmacol       Date:  2007-09-17       Impact factor: 8.739

5.  Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism.

Authors:  Jonathan Z Long; Daniel K Nomura; Benjamin F Cravatt
Journal:  Chem Biol       Date:  2009-07-31

Review 6.  Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

Authors:  Emma K Farrell; David J Merkler
Journal:  Drug Discov Today       Date:  2008-04-03       Impact factor: 7.851

Review 7.  Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

Authors:  Kay Ahn; Michele K McKinney; Benjamin F Cravatt
Journal:  Chem Rev       Date:  2008-04-23       Impact factor: 60.622

Review 8.  Phytocannabinoids beyond the Cannabis plant - do they exist?

Authors:  Jürg Gertsch; Roger G Pertwee; Vincenzo Di Marzo
Journal:  Br J Pharmacol       Date:  2010-06       Impact factor: 8.739

9.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

Review 10.  Endocannabinoids and the heart.

Authors:  C Robin Hiley
Journal:  J Cardiovasc Pharmacol       Date:  2009-04       Impact factor: 3.105

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