Literature DB >> 17655503

PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.

François Lépine1, Valérie Dekimpe, Biliana Lesic, Sylvain Milot, Alain Lesimple, Orval A Mamer, Laurence G Rahme, Eric Déziel.   

Abstract

A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria Pseudomonas aeruginosa and Burkholderia thailandensis. We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is a product of the pqsABCDE operon responsible for the synthesis of 4-hydroxy-2-alkylquinolines (HAQs) in P. aeruginosa. However, DHQ is not a degradation product or precursor of HAQs. This finding sheds some light on the poorly understood biosynthesis pathway of HAQs, which includes important communication signals regulating the expression of virulence factors.

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Year:  2007        PMID： 17655503      PMCID： PMC5115913          DOI： 10.1515/BC.2007.100

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  27 in total

1.  Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa.

Authors:  Dana S Wade; M Worth Calfee; Edson R Rocha; Elizabeth A Ling; Elana Engstrom; James P Coleman; Everett C Pesci
Journal:  J Bacteriol       Date:  2005-07       Impact factor: 3.490

2.  Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa.

Authors:  Larry A Gallagher; Susan L McKnight; Marina S Kuznetsova; Everett C Pesci; Colin Manoil
Journal:  J Bacteriol       Date:  2002-12       Impact factor: 3.490

Review 3.  Targeting mechanisms of Pseudomonas aeruginosa pathogenesis.

Authors:  E Kipnis; T Sawa; J Wiener-Kronish
Journal:  Med Mal Infect       Date:  2006-01-19       Impact factor: 2.152

4.  Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications.

Authors:  D W Essar; L Eberly; A Hadero; I P Crawford
Journal:  J Bacteriol       Date:  1990-02       Impact factor: 3.490

Review 5.  Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing.

Authors:  C Fuqua; M R Parsek; E P Greenberg
Journal:  Annu Rev Genet       Date:  2001       Impact factor: 16.830

6.  MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands.

Authors:  Gaoping Xiao; Eric Déziel; Jianxin He; François Lépine; Biliana Lesic; Marie-Hélène Castonguay; Sylvain Milot; Anastasia P Tampakaki; Scott E Stachel; Laurence G Rahme
Journal:  Mol Microbiol       Date:  2006-12       Impact factor: 3.501

7.  Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase.

Authors:  Oleg Kurnasov; Lynn Jablonski; Boris Polanuyer; Pieter Dorrestein; Tadhg Begley; Andrei Osterman
Journal:  FEMS Microbiol Lett       Date:  2003-10-24       Impact factor: 2.742

8.  The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR.

Authors:  Stephen P Diggle; Klaus Winzer; Siri Ram Chhabra; Kathryn E Worrall; Miguel Cámara; Paul Williams
Journal:  Mol Microbiol       Date:  2003-10       Impact factor: 3.501

9.  Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa.

Authors:  François Lépine; Sylvain Milot; Eric Déziel; Jianxin He; Laurence G Rahme
Journal:  J Am Soc Mass Spectrom       Date:  2004-06       Impact factor: 3.109

10.  [Biosynthesis of 2-n-alkyl-4-hydroxyquinoline derivates (pseudane) in Pseudomonas aeruginosa].

Authors:  C Ritter; M Luckner
Journal:  Eur J Biochem       Date:  1971-02-01
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  19 in total

1.  Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation.

Authors:  Ying Zhuo; Lin Liu; Qi Wang; Xiangyang Liu; Biao Ren; Mei Liu; Peixiang Ni; Yi-Qiang Cheng; Lixin Zhang
Journal:  J Bacteriol       Date:  2012-09       Impact factor: 3.490

2.  Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption.

Authors:  Damien Maura; Laurence G Rahme
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191

3.  Homeostatic interplay between bacterial cell-cell signaling and iron in virulence.

Authors:  Ronen Hazan; Jianxin He; Gaoping Xiao; Valérie Dekimpe; Yiorgos Apidianakis; Biliana Lesic; Christos Astrakas; Eric Déziel; François Lépine; Laurence G Rahme
Journal:  PLoS Pathog       Date:  2010-03-12       Impact factor: 6.823

4.  The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids.

Authors:  Carlos Eduardo Dulcey; Valérie Dekimpe; David-Alexandre Fauvelle; Sylvain Milot; Marie-Christine Groleau; Nicolas Doucet; Laurence G Rahme; François Lépine; Eric Déziel
Journal:  Chem Biol       Date:  2013-11-14

5.  PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.

Authors:  Yong-Mei Zhang; Matthew W Frank; Kun Zhu; Anand Mayasundari; Charles O Rock
Journal:  J Biol Chem       Date:  2008-08-26       Impact factor: 5.157

6.  Quorum sensing modulates colony morphology through alkyl quinolones in Pseudomonas aeruginosa.

Authors:  Rashmi Gupta; Martin Schuster
Journal:  BMC Microbiol       Date:  2012-03-09       Impact factor: 3.605

Review 7.  Quinolones: from antibiotics to autoinducers.

Authors:  Stephan Heeb; Matthew P Fletcher; Siri Ram Chhabra; Stephen P Diggle; Paul Williams; Miguel Cámara
Journal:  FEMS Microbiol Rev       Date:  2011-03       Impact factor: 16.408

8.  A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.

Authors:  Meenu Kesarwani; Ronen Hazan; Jianxin He; Yok-Ai Que; Yokai Que; Yiorgos Apidianakis; Biliana Lesic; Gaoping Xiao; Valérie Dekimpe; Sylvain Milot; Eric Deziel; François Lépine; Laurence G Rahme
Journal:  PLoS Pathog       Date:  2011-08-04       Impact factor: 6.823

9.  Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm.

Authors:  J M Thornton; J M Walker; P Y Kadiyam Sundarasivarao; B W Spur; A Rodriguez; K Yin
Journal:  Prostaglandins Other Lipid Mediat       Date:  2020-11-03       Impact factor: 3.072

10.  Production of Pseudomonas aeruginosa Intercellular Small Signaling Molecules in Human Burn Wounds.

Authors:  Yok-Ai Que; Ronen Hazan; Colleen M Ryan; Sylvain Milot; François Lépine; Martha Lydon; Laurence G Rahme
Journal:  J Pathog       Date:  2011-03-17
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