Literature DB >> 1765147

Cloning and functional characterization of a cocaine-sensitive dopamine transporter.

B Giros1, S el Mestikawy, L Bertrand, M G Caron.   

Abstract

We report the cloning of a rat cDNA encoding a functional dopamine transporter. This cDNA, derived from an intron-containing gene, encodes a protein of 620 amino acids. Hydropathicity analysis of the protein sequence suggests the presence of 12 putative transmembrane domains. The protein displays considerable identity with transporters for noradrenaline and GABA (64 and 30%, respectively). Transient expression of the cDNA in COS7 cells directs the expression of dopamine uptake activity with appropriate pharmacology and in a sodium-dependent fashion. In situ hybridization reveals that the mRNA for this transporter is expressed in the substantia nigra and ventral tegmental area, regions that contain dopaminergic cell bodies.

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Year:  1991        PMID： 1765147     DOI： 10.1016/0014-5793(91)81406-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  54 in total

1.  Involvement of the NH2 terminal domain of catecholamine transporters in the Na(2+) and Cl(-)-dependence of a [3H]-dopamine uptake.

Authors:  M Syringas; F Janin; B Giros; J Costentin; J J Bonnet
Journal:  Br J Pharmacol       Date:  2001-06       Impact factor: 8.739

2.  The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.

Authors:  M J Nirenberg; J Chan; A Pohorille; R A Vaughan; G R Uhl; M J Kuhar; V M Pickel
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

Review 3.  The solute carrier 6 family of transporters.

Authors:  Stefan Bröer; Ulrik Gether
Journal:  Br J Pharmacol       Date:  2012-09       Impact factor: 8.739

4.  Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.

Authors:  Nicole K Speed; Heinrich J G Matthies; J Phillip Kennedy; Roxanne A Vaughan; Jonathan A Javitch; Scott J Russo; Craig W Lindsley; Kevin Niswender; Aurelio Galli
Journal:  ACS Chem Neurosci       Date:  2010-05-25       Impact factor: 4.418

Review 5.  Establishing causality for dopamine in neural function and behavior with optogenetics.

Authors:  Elizabeth E Steinberg; Patricia H Janak
Journal:  Brain Res       Date:  2012-09-29       Impact factor: 3.252

6.  A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons.

Authors:  D Lévesque; M P Martres; J Diaz; N Griffon; C H Lammers; P Sokoloff; J C Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

7.  Cocaine binding sites in fetal rat brain: implications for prenatal cocaine action.

Authors:  J S Meyer; L P Shearman; L M Collins; R L Maguire
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs.

Authors:  O Cases; C Lebrand; B Giros; T Vitalis; E De Maeyer; M G Caron; D J Price; P Gaspar; I Seif
Journal:  J Neurosci       Date:  1998-09-01       Impact factor: 6.167

9.  Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium.

Authors:  K J Buck; S G Amara
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

10.  The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.

Authors:  Ana M Carneiro; Susan L Ingram; Jean-Martin Beaulieu; Ava Sweeney; Susan G Amara; Sheila M Thomas; Marc G Caron; Gonzalo E Torres
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167
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