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Literature DB >> 1765128

Biological aspects of cytosine methylation in eukaryotic cells.

Abstract

The existence in eukaryotes of a fifth base, 5-methylcytosine, and of tissue-specific methylation patterns have been known for many years, but except for a general association with inactive genes and chromatin the exact function of this DNA modification has remained elusive. The different hypotheses regarding the role of DNA methylation in regulation of gene expression, chromatin structure, development, and diseases, including cancer are summarized, and the experimental evidence for them is discussed. Structural and functional properties of the eukaryotic DNA cytosine methyltransferase are also reviewed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1991 PMID： 1765128 DOI： 10.1007/bf01918381

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

208 in total

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Journal: Science Date: 1984-11-16 Impact factor: 47.728

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Journal: Genes Dev Date: 1990-03 Impact factor: 11.361

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Journal: Biochem Biophys Res Commun Date: 1989-05-15 Impact factor: 3.575

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Journal: Genes Dev Date: 1989-11 Impact factor: 11.361

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Journal: Proc Natl Acad Sci U S A Date: 1989-09 Impact factor: 11.205

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Authors: M A Harrington; P A Jones; M Imagawa; M Karin
Journal: Proc Natl Acad Sci U S A Date: 1988-04 Impact factor: 11.205

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Journal: Nucleic Acids Res Date: 1980-04-11 Impact factor: 16.971

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Journal: Proc Natl Acad Sci U S A Date: 1983-09 Impact factor: 11.205

9. Adenovirus type 2 VAI RNA transcription by polymerase III is blocked by sequence-specific methylation.

Authors: R Jüttermann; K Hosokawa; S Kochanek; W Doerfler
Journal: J Virol Date: 1991-04 Impact factor: 5.103

10. Comparison of the 15q deletions in Prader-Willi and Angelman syndromes: specific regions, extent of deletions, parental origin, and clinical consequences.

Authors: R E Magenis; S Toth-Fejel; L J Allen; M Black; M G Brown; S Budden; R Cohen; J M Friedman; D Kalousek; J Zonana
Journal: Am J Med Genet Date: 1990-03

18 in total

Review 1. The influence of base sequence on the immunostimulatory properties of DNA.

Authors: D S Pisetsky
Journal: Immunol Res Date: 1999 Impact factor: 2.829

Review 2. Mechanisms of immune stimulation by bacterial DNA.

Authors: D S Pisetsky
Journal: Springer Semin Immunopathol Date: 2000

3. Identification of genes differentially expressed by calorie restriction in the rotifer (Brachionus plicatilis).

Authors: Aung Kyaw Swar Oo; Gen Kaneko; Makoto Hirayama; Shigeharu Kinoshita; Shugo Watabe
Journal: J Comp Physiol B Date: 2009-07-19 Impact factor: 2.200

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Authors: S U Kass; J P Goddard; R L Adams
Journal: Mol Cell Biol Date: 1993-12 Impact factor: 4.272

Review 5. Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells.

Authors: K Heeg; T Sparwasser; G B Lipford; H Häcker; S Zimmermann; H Wagner
Journal: Eur J Clin Microbiol Infect Dis Date: 1998-07 Impact factor: 3.267

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Authors: D S Pisetsky
Journal: Clin Diagn Lab Immunol Date: 1998-01

7. Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine.

Authors: N Karino; Y Ueno; A Matsuda
Journal: Nucleic Acids Res Date: 2001-06-15 Impact factor: 16.971