Literature DB >> 1765127

Molecular recognition: models for drug design.

R J Breckenridge1.   

Abstract

The review takes examples, mostly from the recent literature, to illustrate how an understanding of physico-chemical properties and an appreciation of the molecular shape and electronic properties can lead to a better insight into molecular recognition processes. The techniques used to generate 3-dimensional structures of molecules and the influence this information has had on the drug design cycle, are briefly discussed.

Mesh:

Substances:

Year:  1991        PMID: 1765127     DOI: 10.1007/bf01918379

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  53 in total

1.  Structures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopy.

Authors:  G M Clore; A M Gronenborn
Journal:  Science       Date:  1991-06-07       Impact factor: 47.728

2.  Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.

Authors:  A R Sielecki; K Hayakawa; M Fujinaga; M E Murphy; M Fraser; A K Muir; C T Carilli; J A Lewicki; J D Baxter; M N James
Journal:  Science       Date:  1989-03-10       Impact factor: 47.728

Review 3.  What can two-dimensional NMR tell us about proteins?

Authors:  P E Wright
Journal:  Trends Biochem Sci       Date:  1989-07       Impact factor: 13.807

4.  The structure of the catecholamines. II. The crystal structure of dopamine hydrochloride.

Authors:  R Bergin; D Carlström
Journal:  Acta Crystallogr B       Date:  1968-11-15       Impact factor: 2.266

5.  Two aspects of DNA polymorphism and microheterogeneity: molecular electrostatic potential and steric accessibility.

Authors:  B Pullman; R Lavery; A Pullman
Journal:  Eur J Biochem       Date:  1982-05-17

6.  Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.

Authors:  J F Davies; T J Delcamp; N J Prendergast; V A Ashford; J H Freisheim; J Kraut
Journal:  Biochemistry       Date:  1990-10-09       Impact factor: 3.162

7.  On the size of the active site in proteases. I. Papain.

Authors:  I Schechter; A Berger
Journal:  Biochem Biophys Res Commun       Date:  1967-04-20       Impact factor: 3.575

8.  Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.

Authors:  R Henderson; J M Baldwin; T A Ceska; F Zemlin; E Beckmann; K H Downing
Journal:  J Mol Biol       Date:  1990-06-20       Impact factor: 5.469

9.  Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.

Authors:  J C Powers; J Oleksyszyn; S L Narasimhan; C M Kam
Journal:  Biochemistry       Date:  1990-03-27       Impact factor: 3.162

10.  The structure of a complex of recombinant hirudin and human alpha-thrombin.

Authors:  T J Rydel; K G Ravichandran; A Tulinsky; W Bode; R Huber; C Roitsch; J W Fenton
Journal:  Science       Date:  1990-07-20       Impact factor: 47.728

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.