| Literature DB >> 17649989 |
Grégory Durand1, Burkhard Poeggeler, Jutta Böker, Simon Raynal, Ange Polidori, Miguel A Pappolla, Rüdiger Hardeland, Bernard Pucci.
Abstract
A new series of hydrophilic, lipophilic, and amphiphilic alpha-phenyl-N-tert-butylnitrone (PBN) derivatives were synthesized to explore the relationship between their hydrophilic-lipophilic properties and antioxidant potency. Very potent protective effects of amphiphilic lactobionamide and tris(hydroxymethyl)aminomethane PBN derivatives were observed in mitochondrial preparations, in cell cultures, and in rotifers exposed to unspecific and mitochondria targeted oxidotoxins.Entities:
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Year: 2007 PMID： 17649989 DOI： 10.1021/jm0706968
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446