| Literature DB >> 17646033 |
Mariela M Gironacci1, K Bridget Brosnihan, Carlos M Ferrario, Susana Gorzalczany, María A Lopez Verrilli, Mariano Pascual, Carlos Taira, Clara Peña.
Abstract
Since angiotensin (Ang) (1-7) injected into the brain blocked Ang II pressor actions in rats made hypertensive by aortic coarctation (CH), we examined systemic and tissue angiotensin peptide levels, specifically concentrating on the hypothalamic Ang-(1-7) levels. Plasma, heart and kidney isolated from CH rats showed increased levels of Ang I, Ang II and Ang-(1-7) compared with the normotensive group, with Ang II being the predominant peptide in heart and kidney. In the hypothalamus, equimolar amounts of Ang II and Ang-(1-7) were found in the sham group, whereas only Ang-(1-7) levels increased in CH rats. We conclude that aortic coarctation activates systemic and tissue renin-angiotensin system. The increased central levels of Ang-(1-7) in the CH rats suggest a potential mitigating role of this peptide in central control of the hypertensive process.Entities:
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Year: 2007 PMID： 17646033 PMCID： PMC2045136 DOI： 10.1016/j.peptides.2007.06.016
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750