OBJECTIVE: To determine the optimal timing for orchiopexy, we evaluated the histological parameters of the cryptorchid testis. METHODS: We prospectively performed testicular biopsy in a total of 65 consecutive children with palpable unilateral inguinal cryptorchid testes. For controls, we used testicular histological slides from 15 age-matched children with testicular tumor. To investigate the fertility potential, we analyzed the parameters including mean tubular diameter (MTD), mean tubular fertility index (MTFI), germ cell count/tubule (GCC), Sertoli cell index (SCI) and interstitial fibrosis index (IFI). RESULTS: The MTFI and GCC in children < or =1 years of age were significantly higher than those of other older age groups. The MTFI, GCC and IFI were significantly better in patients < or =2 years of age when compared to those of > 2 years. Compared to the controls, the MTFI and GCC in the patients were significantly worse in those aged > 2 years at surgical repair. In the < or =2-year age group, the MTFI and GCC of the cryptorchid testis showed a decreasing tendency with age, which were contrasting with the ascending curves in the control and the curves crossed at 1-2 years of age in each parameter. CONCLUSIONS: To protect fertility potential, we recommend, orchiopexy should be performed within the first year of life, and no later than 2 years of age in patients with palpable inguinal cryptorchid testes.
OBJECTIVE: To determine the optimal timing for orchiopexy, we evaluated the histological parameters of the cryptorchid testis. METHODS: We prospectively performed testicular biopsy in a total of 65 consecutive children with palpable unilateral inguinal cryptorchid testes. For controls, we used testicular histological slides from 15 age-matched children with testicular tumor. To investigate the fertility potential, we analyzed the parameters including mean tubular diameter (MTD), mean tubular fertility index (MTFI), germ cell count/tubule (GCC), Sertoli cell index (SCI) and interstitial fibrosis index (IFI). RESULTS: The MTFI and GCC in children < or =1 years of age were significantly higher than those of other older age groups. The MTFI, GCC and IFI were significantly better in patients < or =2 years of age when compared to those of > 2 years. Compared to the controls, the MTFI and GCC in the patients were significantly worse in those aged > 2 years at surgical repair. In the < or =2-year age group, the MTFI and GCC of the cryptorchid testis showed a decreasing tendency with age, which were contrasting with the ascending curves in the control and the curves crossed at 1-2 years of age in each parameter. CONCLUSIONS: To protect fertility potential, we recommend, orchiopexy should be performed within the first year of life, and no later than 2 years of age in patients with palpable inguinal cryptorchid testes.
Authors: Ramesh Mark Nataraja; Evie Yeap; Costa J Healy; Inderpal S Nandhra; Feilim L Murphy; John M Hutson; Chris Kimber Journal: Pediatr Surg Int Date: 2017-11-09 Impact factor: 1.827
Authors: Georg Hrivatakis; Wolfgang Astfalk; Andreas Schmidt; Andreas Hartwig; Thomas Kugler; Thomas Heim; Axel Clausner; Albrecht Frunder; Harduin Weber; Steffan Loff; Joerg Fuchs; Verena Ellerkamp Journal: Dtsch Arztebl Int Date: 2014-09-26 Impact factor: 5.594
Authors: Jenny H Yiee; Christopher S Saigal; Julie Lai; Hillary L Copp; Bernard M Churchill; Mark S Litwin Journal: Urology Date: 2012-11 Impact factor: 2.649