Literature DB >> 17643302

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation.

Aiming Sun1, Nizal Chandrakumar, Jeong-Joong Yoon, Richard K Plemper, James P Snyder.   

Abstract

High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC(50)=35-145 nM) inhibitor against multiple primary isolates of diverse measles virus (MV) genotypes currently circulating worldwide. The synthesis of 16677 and several analogs together with effects on MV replication is described. The most potent analog displays nanomolar inhibition against the MV and a selectivity ratio (CC(50)/IC(50)) of ca. 16,500.

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Year:  2007        PMID： 17643302      PMCID： PMC2100383          DOI： 10.1016/j.bmcl.2007.06.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

Review 1.  Current overview of the pathogenesis and prophylaxis of measles with focus on practical implications.

Authors:  M R Hilleman
Journal:  Vaccine       Date:  2001-12-12       Impact factor: 3.641

2.  Two domains that control prefusion stability and transport competence of the measles virus fusion protein.

Authors:  Joshua Doyle; Andrew Prussia; Laura K White; Aiming Sun; Dennis C Liotta; James P Snyder; Richard W Compans; Richard K Plemper
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

3.  Nonpeptide inhibitors of measles virus entry.

Authors:  Aiming Sun; Andrew Prussia; Weiqiang Zhan; Ernest E Murray; Joshua Doyle; Li-Ting Cheng; Jeong-Joong Yoon; Eugene V Radchenko; Vladimir A Palyulin; Richard W Compans; Dennis C Liotta; Richard K Plemper; James P Snyder
Journal:  J Med Chem       Date:  2006-08-24       Impact factor: 7.446

4.  Design of a small-molecule entry inhibitor with activity against primary measles virus strains.

Authors:  Richard K Plemper; Joshua Doyle; Aiming Sun; Andrew Prussia; Li-Ting Cheng; Paul A Rota; Dennis C Liotta; James P Snyder; Richard W Compans
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

5.  Antiviral activities of ribavirin, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide, and 6'-(R)-6'-C-methylneplanocin A against several ortho- and paramyxoviruses.

Authors:  S Shigeta; S Mori; M Baba; M Ito; K Honzumi; K Nakamura; H Oshitani; Y Numazaki; A Matsuda; T Obara
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

6.  Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity.

Authors:  Laura K White; Jeong-Joong Yoon; Jin K Lee; Aiming Sun; Yuhong Du; Haian Fu; James P Snyder; Richard K Plemper
Journal:  Antimicrob Agents Chemother       Date:  2007-04-30       Impact factor: 5.191

7.  Structural features of paramyxovirus F protein required for fusion initiation.

Authors:  Richard K Plemper; Ami S Lakdawala; Kim M Gernert; James P Snyder; Richard W Compans
Journal:  Biochemistry       Date:  2003-06-10       Impact factor: 3.162

8.  A target site for template-based design of measles virus entry inhibitors.

Authors:  Richard K Plemper; Karl J Erlandson; Ami S Lakdawala; Aiming Sun; Andrew Prussia; Jutatip Boonsombat; Esin Aki-Sener; Ismail Yalcin; Ilkay Yildiz; Ozlem Temiz-Arpaci; Betul Tekiner; Dennis C Liotta; James P Snyder; Richard W Compans
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-31       Impact factor: 11.205

Review 9.  Inhibitors of measles virus.

Authors:  Dale L Barnard
Journal:  Antivir Chem Chemother       Date:  2004-05

10.  Fluorinated derivatives of benz[4,5]imidazo[1,2-b][1,3] thiazole--inhibitors of reproduction of measles virus.

Authors:  A G Pokrovskii; T N Il'icheva; S K Kotovskaya; S A Romanova; V N Charushin; O N Chupakhin
Journal:  Dokl Biochem Biophys       Date:  2004 Sep-Oct       Impact factor: 0.788
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  17 in total

1.  Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor.

Authors:  Venice Du Pont; Christoph Wirblich; Jeong-Joong Yoon; Robert M Cox; Matthias J Schnell; Richard K Plemper
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

Review 2.  Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors:  Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

3.  Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.

Authors:  J Maina Ndungu; Stefanie A Krumm; Dan Yan; Richard F Arrendale; G Prabhakar Reddy; Taylor Evers; Randy Howard; Michael G Natchus; Manohar T Saindane; Dennis C Liotta; Richard K Plemper; James P Snyder; Aiming Sun
Journal:  J Med Chem       Date:  2012-04-20       Impact factor: 7.446

4.  Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation.

Authors:  Aiming Sun; J Maina Ndungu; Stefanie A Krumm; Jeong-Joong Yoon; Pahk Thepchatri; Michael Natchus; Richard K Plemper; James P Snyder
Journal:  ACS Med Chem Lett       Date:  2011-08-23       Impact factor: 4.345

5.  High-throughput screening-based identification of paramyxovirus inhibitors.

Authors:  Jeong-Joong Yoon; Dhruv Chawla; Tanja Paal; Maina Ndungu; Yuhong Du; Serdar Kurtkaya; Aiming Sun; James P Snyder; Richard K Plemper
Journal:  J Biomol Screen       Date:  2008-07-14

6.  Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex.

Authors:  Aiming Sun; Jeong-Joong Yoon; Yan Yin; Andrew Prussia; Yutao Yang; Jaeki Min; Richard K Plemper; James P Snyder
Journal:  J Med Chem       Date:  2008-06-05       Impact factor: 7.446

Review 7.  Measles control--can measles virus inhibitors make a difference?

Authors:  Richard K Plemper; James P Snyder
Journal:  Curr Opin Investig Drugs       Date:  2009-08

Review 8.  Cancer and virus leads by HTS, chemical design and SEA data mining.

Authors:  Pahk Thepchatri; Jaeki Min; Thota Ganesh; Yuhong Du; Iestyn Lewis; Serdar Kurtkaya; Andrew Prussia; Lian Li; Blossom Sneed; Richard K Plemper; Haian Fu; Dennis C Liotta; James P Snyder; Raymond Dingledine; Aiming Sun
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

Review 9.  Synergizing vaccinations with therapeutics for measles eradication.

Authors:  Richard K Plemper; Anthea L Hammond
Journal:  Expert Opin Drug Discov       Date:  2013-12-05       Impact factor: 6.098

10.  Target analysis of the experimental measles therapeutic AS-136A.

Authors:  Jeong-Joong Yoon; Stefanie A Krumm; J Maina Ndungu; Vanessa Hoffman; Bettina Bankamp; Paul A Rota; Aiming Sun; James P Snyder; Richard K Plemper
Journal:  Antimicrob Agents Chemother       Date:  2009-06-15       Impact factor: 5.191
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