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Literature DB >> 17638697

Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol.

Christopher C Miller¹, Mamta Rawat, Todd Johnson, Yossef Av-Gay.

Abstract

Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

Entities: Chemical Species

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Year: 2007 PMID： 17638697 PMCID： PMC2043170 DOI： 10.1128/AAC.00347-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

1. Oxygen binding and NO scavenging properties of truncated hemoglobin, HbN, of Mycobacterium smegmatis.

Authors: Amrita Lama; Sudesh Pawaria; Kanak L Dikshit
Journal: FEBS Lett Date: 2006-06-22 Impact factor: 4.124

2. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.

Authors: R Bryk; C D Lima; H Erdjument-Bromage; P Tempst; C Nathan
Journal: Science Date: 2002-01-17 Impact factor: 47.728

3. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.

Authors: G L Newton; Y Av-Gay; R C Fahey
Journal: Biochemistry Date: 2000-09-05 Impact factor: 3.162

4. Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli.

Authors: Ranjana Pathania; Naveen K Navani; Anne M Gardner; Paul R Gardner; Kanak L Dikshit
Journal: Mol Microbiol Date: 2002-09 Impact factor: 3.501

5. Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein.

Authors: Mamta Rawat; Mandeep Uppal; Gerald Newton; Micah Steffek; Robert C Fahey; Yossef Av-Gay
Journal: J Bacteriol Date: 2004-09 Impact factor: 3.490

6. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

Authors: Gerald L Newton; Teresa Koledin; Batia Gorovitz; Mamta Rawat; Robert C Fahey; Yossef Av-Gay
Journal: J Bacteriol Date: 2003-06 Impact factor: 3.490

7. Oxidative stress response genes in Mycobacterium tuberculosis: role of ahpC in resistance to peroxynitrite and stage-specific survival in macrophages.

Authors: S S Master; B Springer; P Sander; E C Boettger; V Deretic; G S Timmins
Journal: Microbiology Date: 2002-10 Impact factor: 2.777

8. Kinetics of nitrosation of thiols by nitric oxide in the presence of oxygen.

Authors: V G Kharitonov; A R Sundquist; V S Sharma
Journal: J Biol Chem Date: 1995-11-24 Impact factor: 5.157

9. The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.

Authors: Ryan N Vogt; Daniel J Steenkamp; Renjian Zheng; John S Blanchard
Journal: Biochem J Date: 2003-09-15 Impact factor: 3.857

10. Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst.

Authors: Vincent H Ng; Jeffery S Cox; Alexandra O Sousa; John D MacMicking; John D McKinney
Journal: Mol Microbiol Date: 2004-06 Impact factor: 3.501

11 in total

1. Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: a phase I clinical study.

Authors: Caroline Deppisch; Gloria Herrmann; Ute Graepler-Mainka; Hubertus Wirtz; Susanne Heyder; Corinna Engel; Matthias Marschal; Christopher C Miller; Joachim Riethmüller
Journal: Infection Date: 2016-02-09 Impact factor: 3.553

2. Examination of bacterial resistance to exogenous nitric oxide.

Authors: Benjamin J Privett; Angela D Broadnax; Susanne J Bauman; Daniel A Riccio; Mark H Schoenfisch
Journal: Nitric Oxide Date: 2012-02-18 Impact factor: 4.427

Review 3. Bacillithiol, a new player in bacterial redox homeostasis.

Authors: John D Helmann
Journal: Antioxid Redox Signal Date: 2010-12-17 Impact factor: 8.401

4. Slow release of nitric oxide from charged catheters and its effect on biofilm formation by Escherichia coli.

Authors: Gilly Regev-Shoshani; Mary Ko; Chris Miller; Yossef Av-Gay
Journal: Antimicrob Agents Chemother Date: 2009-11-02 Impact factor: 5.191

5. Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.

Authors: Melissa Richard-Greenblatt; Horacio Bach; John Adamson; Sandra Peña-Diaz; Wu Li; Adrie J C Steyn; Yossef Av-Gay
Journal: J Biol Chem Date: 2015-07-30 Impact factor: 5.157

6. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.

Authors: Vikram Saini; Bridgette M Cumming; Loni Guidry; Dirk A Lamprecht; John H Adamson; Vineel P Reddy; Krishna C Chinta; James H Mazorodze; Joel N Glasgow; Melissa Richard-Greenblatt; Anaximandro Gomez-Velasco; Horacio Bach; Yossef Av-Gay; Hyungjin Eoh; Kyu Rhee; Adrie J C Steyn
Journal: Cell Rep Date: 2016-01-07 Impact factor: 9.423