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Literature DB >> 12754249

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

Gerald L Newton¹, Teresa Koledin, Batia Gorovitz, Mamta Rawat, Robert C Fahey, Yossef Av-Gay.

Abstract

Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.

Entities: Chemical Species

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Year: 2003 PMID： 12754249 PMCID： PMC155378 DOI： 10.1128/JB.185.11.3476-3479.2003

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

21 in total

1. Identification of essential amino acids in the bacterial alpha -mannosyltransferase aceA.

Authors: P L Abdian; A C Lellouch; C Gautier; L Ielpi; R A Geremia
Journal: J Biol Chem Date: 2000-12-22 Impact factor: 5.157

2. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.

Authors: G L Newton; Y Av-Gay; R C Fahey
Journal: J Bacteriol Date: 2000-12 Impact factor: 3.490

Review 3. Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.

Authors: T Kinoshita; N Inoue
Journal: Curr Opin Chem Biol Date: 2000-12 Impact factor: 8.822

4. ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases.

Authors: Dipti Sareen; Micah Steffek; Gerald L Newton; Robert C Fahey
Journal: Biochemistry Date: 2002-06-04 Impact factor: 3.162

5. Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis.

Authors: Koen A L De Smet; Karen E Kempsell; Alex Gallagher; Ken Duncan; Douglas B Young
Journal: Microbiology (Reading) Date: 1999-11 Impact factor: 2.777

6. Photoaffinity labelling with P3-(4-azidoanilido)uridine 5'-triphosphate identifies gpi3p as the UDP-GlcNAc-binding subunit of the enzyme that catalyses formation of GlcNAc-phosphatidylinositol, the first glycolipid intermediate in glycosylphosphatidylinositol synthesis.

Authors: Z Kostova; D M Rancour; A K Menon; P Orlean
Journal: Biochem J Date: 2000-09-15 Impact factor: 3.857

7. Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Authors: Laurent Kremer; Sudagar S Gurcha; Pablo Bifani; Paul G Hitchen; Alain Baulard; Howard R Morris; Anne Dell; Patrick J Brennan; Gurdyal S Besra
Journal: Biochem J Date: 2002-05-01 Impact factor: 3.857

8. Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.

Authors: G L Newton; M D Unson; S J Anderberg; J A Aguilera; N N Oh; S B delCardayre; Y Av-Gay; R C Fahey
Journal: Biochem Biophys Res Commun Date: 1999-02-16 Impact factor: 3.575

9. Sucrose metabolism: Anabaena sucrose-phosphate synthase and sucrose-phosphate phosphatase define minimal functional domains shuffled during evolution.

Authors: Andrea Cumino; Leonardo Curatti; Laura Giarrocco; Graciela L Salerno
Journal: FEBS Lett Date: 2002-04-24 Impact factor: 4.124

10. Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB.

Authors: Y Av-Gay; S Jamil; S J Drews
Journal: Infect Immun Date: 1999-11 Impact factor: 3.441

32 in total

1. Intramolecular alpha-glucosaminidation: synthesis of mycothiol.

Authors: Kehinde Ajayi; Vinay V Thakur; Robert C Lapo; Spencer Knapp
Journal: Org Lett Date: 2010-06-04 Impact factor: 6.005

Review 2. New targets and inhibitors of mycobacterial sulfur metabolism.

Authors: Hanumantharao Paritala; Kate S Carroll
Journal: Infect Disord Drug Targets Date: 2013-04

3. S-nitrosomycothiol reductase and mycothiol are required for survival under aldehyde stress and biofilm formation in Mycobacterium smegmatis.

Authors: Derek Vargas; Samantha Hageman; Megha Gulati; Clarissa J Nobile; Mamta Rawat
Journal: IUBMB Life Date: 2016-06-19 Impact factor: 3.885

4. Compounds with Potential Activity against Mycobacterium tuberculosis.

Authors: B Baker; C Carolis; C Sao Emani; M J Williams; I J Wiid
Journal: Antimicrob Agents Chemother Date: 2018-03-27 Impact factor: 5.191

5. Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman.

Authors: Dipti Sareen; Gerald L Newton; Robert C Fahey; Nancy A Buchmeier
Journal: J Bacteriol Date: 2003-11 Impact factor: 3.490

6. A Structural, Functional, and Computational Analysis of BshA, the First Enzyme in the Bacillithiol Biosynthesis Pathway.

Authors: Kelsey R Winchell; Paul W Egeler; Andrew J VanDuinen; Luke B Jackson; Mary E Karpen; Paul D Cook
Journal: Biochemistry Date: 2016-08-11 Impact factor: 3.162