BACKGROUND: Performance of endoscopy within 24 h is recommended for patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB). It is unknown whether performing endoscopy early within this 24 h window is beneficial for clinically high-risk patients. METHODS: A retrospective review was performed to identify patients presenting to two tertiary care centres with ANVUGIB and either systolic blood pressure lower than 100 mmHg or heart rate greater than 100 beats/min on presentation between 1999 and 2004. Patients receiving endoscopy within 6 h (rapid endoscopy [RE]) were compared with patients undergoing endoscopy between 6 h and 24 h (early endoscopy [EE]). The primary outcome measure was the development of any adverse bleeding outcome (rebleeding, surgery for control of bleeding, in-hospital mortality or readmission within 30 days for ANVUGIB). RESULTS: There were 169 patients who met the entry criteria (77 RE patients and 92 EE patients). There was no significant difference in the development of any adverse bleeding outcomes between RE and EE patients (25% RE versus 23% EE, difference between groups 2%, 95% CI --9% to 13%). Transfusion requirements and length of hospital stay also did not differ between the comparator groups. RE was not associated with fewer adverse outcomes, even after adjusting for confounders. CONCLUSION: For clinically high-risk ANVUGIB patients, performing endoscopy within 6 h of presentation is no more effective than performing endoscopy between 6 h and 24 h after presentation. The role of RE in high-risk ANVUGIB patients requires further delineation in a prospective fashion.
BACKGROUND: Performance of endoscopy within 24 h is recommended for patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB). It is unknown whether performing endoscopy early within this 24 h window is beneficial for clinically high-risk patients. METHODS: A retrospective review was performed to identify patients presenting to two tertiary care centres with ANVUGIB and either systolic blood pressure lower than 100 mmHg or heart rate greater than 100 beats/min on presentation between 1999 and 2004. Patients receiving endoscopy within 6 h (rapid endoscopy [RE]) were compared with patients undergoing endoscopy between 6 h and 24 h (early endoscopy [EE]). The primary outcome measure was the development of any adverse bleeding outcome (rebleeding, surgery for control of bleeding, in-hospital mortality or readmission within 30 days for ANVUGIB). RESULTS: There were 169 patients who met the entry criteria (77 RE patients and 92 EE patients). There was no significant difference in the development of any adverse bleeding outcomes between RE and EE patients (25% RE versus 23% EE, difference between groups 2%, 95% CI --9% to 13%). Transfusion requirements and length of hospital stay also did not differ between the comparator groups. RE was not associated with fewer adverse outcomes, even after adjusting for confounders. CONCLUSION: For clinically high-risk ANVUGIB patients, performing endoscopy within 6 h of presentation is no more effective than performing endoscopy between 6 h and 24 h after presentation. The role of RE in high-risk ANVUGIB patients requires further delineation in a prospective fashion.
Authors: J G Lee; S Turnipseed; P S Romano; H Vigil; R Azari; N Melnikoff; R Hsu; D Kirk; P Sokolove; J W Leung Journal: Gastrointest Endosc Date: 1999-12 Impact factor: 9.427
Authors: Keith Siau; James Hodson; Richard Ingram; Andrew Baxter; Monika M Widlak; Caroline Sharratt; Graham M Baker; Tom Troth; Ben Hicken; Faraz Tahir; Malik Magrabi; Nouman Yousaf; Claire Grant; Dennis Poon; Hesham Khalil; Hui Lin Lee; Jonathan R White; Huey Tan; Syazeddy Samani; Patricia Hooper; Saeed Ahmed; Muhammad Amin; Sara Mahgoub; Khayal Asghar; Farique Leet; Matthew J Harborne; Beata Polewiczowska; Sheeba Khan; Muhammad R Anjum; Michael McFarlane; Ella Mozdiak; Lauren D O'Flynn; Ilona C Blee; Rachel M Molyneux; Ashok Kurian; Syed N Abbas; Abdullah Abbasi; Aadil Karim; Asif Yasin; Fawad Khattak; Josephine White; Ruhina Ahmed; James A Morgan; Lance Alleyne; Mohamed A Alam; Naaventhan Palaniyappan; Victoria J Rodger; Paramvir Sawhney; Nasar Aslam; Theodore Okeke; Adam Lawson; Danny Cheung; Jeremy P Reid; Ashish Awasthi; Mark R Anderson; Joe R Timothy; Sanjeev Pattni; Saqib Ahmad; Gillian Townson; Jeremy Shearman; Vanja Giljaca; Matthew J Brookes; Ben R Disney; Neil Guha; Titus Thomas; Anthony Norman; Peter Wurm; Ashit Shah; Neil C Fisher; Sauid Ishaq; Giles Major Journal: United European Gastroenterol J Date: 2018-10-28 Impact factor: 4.623