Literature DB >> 17637770

Scaffold composition and biological relevance of screening libraries.

Anang A Shelat1, R Kiplin Guy.   

Abstract

The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

Mesh：

Substances：

Year:  2007        PMID： 17637770     DOI： 10.1038/nchembio0807-442

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  44 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

Review 2.  Global phenotypic screening for antimalarials.

Authors:  W Armand Guiguemde; Anang A Shelat; Jose F Garcia-Bustos; Thierry T Diagana; Francisco-Javier Gamo; R Kiplin Guy
Journal:  Chem Biol       Date:  2012-01-27

3.  A road less traveled by: exploring a decade of Ellman chemistry.

Authors:  Anang A Shelat; R Kiplin Guy
Journal:  Bioorg Med Chem       Date:  2008-03-04       Impact factor: 3.641

Review 4.  Chemical probes and drug leads from advances in synthetic planning and methodology.

Authors:  Christopher J Gerry; Stuart L Schreiber
Journal:  Nat Rev Drug Discov       Date:  2018-04-13       Impact factor: 84.694

5.  Diversity-oriented synthesis of macrocyclic peptidomimetics.

Authors:  Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

6.  Cycloisomerization of Olefins in Water.

Authors:  Jeishla L M Matos; Samantha A Green; Yuge Chun; Vuong Q Dang; Russell G Dushin; Paul Richardson; Jason S Chen; David W Piotrowski; Brian M Paegel; Ryan A Shenvi
Journal:  Angew Chem Int Ed Engl       Date:  2020-05-28       Impact factor: 15.336

7.  Chemical genetics of Plasmodium falciparum.

Authors:  W Armand Guiguemde; Anang A Shelat; David Bouck; Sandra Duffy; Gregory J Crowther; Paul H Davis; David C Smithson; Michele Connelly; Julie Clark; Fangyi Zhu; María B Jiménez-Díaz; María S Martinez; Emily B Wilson; Abhai K Tripathi; Jiri Gut; Elizabeth R Sharlow; Ian Bathurst; Farah El Mazouni; Joseph W Fowble; Isaac Forquer; Paula L McGinley; Steve Castro; Iñigo Angulo-Barturen; Santiago Ferrer; Philip J Rosenthal; Joseph L Derisi; David J Sullivan; John S Lazo; David S Roos; Michael K Riscoe; Margaret A Phillips; Pradipsinh K Rathod; Wesley C Van Voorhis; Vicky M Avery; R Kiplin Guy
Journal:  Nature       Date:  2010-05-20       Impact factor: 49.962

8.  Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen.

Authors:  Tinatin I Brelidze; Anne E Carlson; Douglas R Davies; Lance J Stewart; William N Zagotta
Journal:  PLoS One       Date:  2010-09-02       Impact factor: 3.240

9.  Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

Authors:  Daniel A Bachovchin; Steven J Brown; Hugh Rosen; Benjamin F Cravatt
Journal:  Nat Biotechnol       Date:  2009-03-29       Impact factor: 54.908

10.  2D depiction of fragment hierarchies.

Authors:  Alex M Clark
Journal:  J Chem Inf Model       Date:  2010-01       Impact factor: 4.956
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.