METHODS: Between January 1990 and November 2006, 65 consecutive childhood cancer survivors entered a prospective follow-up study to evaluate the frequency and severity of tumor- and/or therapy-related long-term sequelae. Their median age at diagnosis was 9.7 years, median actual age is 25.1 years, and median duration of follow-up is 14.8 years. RESULTS: Nine patients (13.9%) were completely free from late effects, whereas 31/65 patients (47.6%) had only minimal late effects without need of medical support and 25/65 patients (38.5%) had severe late effects requiring long-term medical care. The most frequent late effects were endocrine deficits, musculosceletal problems, neurologic problems, chronic hepatitis and hearing loss. Currently, a network of local adult care providers is being established in order to enable a smooth and competent referral from pediatric hemato-oncology to adult medicine. CONCLUSIONS: Two thirds of former childhood cancer patients are able to return to everyday life without any impairment. However, one third is suffering from considerable morbidity requiring long-term medical care. Transition models from pediatric hemato-oncology to adult health care providers are urgently needed.
METHODS: Between January 1990 and November 2006, 65 consecutive childhood cancer survivors entered a prospective follow-up study to evaluate the frequency and severity of tumor- and/or therapy-related long-term sequelae. Their median age at diagnosis was 9.7 years, median actual age is 25.1 years, and median duration of follow-up is 14.8 years. RESULTS: Nine patients (13.9%) were completely free from late effects, whereas 31/65 patients (47.6%) had only minimal late effects without need of medical support and 25/65 patients (38.5%) had severe late effects requiring long-term medical care. The most frequent late effects were endocrine deficits, musculosceletal problems, neurologic problems, chronic hepatitis and hearing loss. Currently, a network of local adult care providers is being established in order to enable a smooth and competent referral from pediatric hemato-oncology to adult medicine. CONCLUSIONS: Two thirds of former childhood cancerpatients are able to return to everyday life without any impairment. However, one third is suffering from considerable morbidity requiring long-term medical care. Transition models from pediatric hemato-oncology to adult health care providers are urgently needed.
Authors: P K Duffner; M E Cohen; M L Voorhess; M H MacGillivray; M L Brecher; A Panahon; B B Gilani Journal: Cancer Date: 1985-11-01 Impact factor: 6.860
Authors: Kevin C Oeffinger; Ann C Mertens; Charles A Sklar; Toana Kawashima; Melissa M Hudson; Anna T Meadows; Debra L Friedman; Neyssa Marina; Wendy Hobbie; Nina S Kadan-Lottick; Cindy L Schwartz; Wendy Leisenring; Leslie L Robison Journal: N Engl J Med Date: 2006-10-12 Impact factor: 176.079
Authors: J P Neglia; D L Friedman; Y Yasui; A C Mertens; S Hammond; M Stovall; S S Donaldson; A T Meadows; L L Robison Journal: J Natl Cancer Inst Date: 2001-04-18 Impact factor: 11.816
Authors: Renée L Mulder; Dorine Bresters; Malon Van den Hof; Bart Gp Koot; Sharon M Castellino; Yoon Kong K Loke; Piet N Post; Aleida Postma; László P Szőnyi; Gill A Levitt; Edit Bardi; Roderick Skinner; Elvira C van Dalen Journal: Cochrane Database Syst Rev Date: 2019-04-15