Literature DB >> 1763426

From linked marker to gene.

C Wicking1, B Williamson.   

Abstract

An area of increasing importance in human genetics research is the strategy of 'reverse genetics' or 'positional cloning', whereby a gene associated with a genetic disease is isolated on the basis of its approximate chromosomal position. This article and the accompanying centrepage diagram describe the main features of this strategy and outline the techniques involved; they are designed to be used for teaching purposes and as a general reference for those from other fields of genetics research.

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Year:  1991        PMID： 1763426     DOI： 10.1016/0168-9525(91)90310-M

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  18 in total

1.  The molecular basis of X-linked spondyloepiphyseal dysplasia tarda.

Authors:  A K Gedeon; G E Tiller; M Le Merrer; S Heuertz; L Tranebjaerg; D Chitayat; S Robertson; I A Glass; R Savarirayan; W G Cole; D L Rimoin; B G Kousseff; H Ohashi; B Zabel; A Munnich; J Gecz; J C Mulley
Journal:  Am J Hum Genet       Date:  2001-05-08       Impact factor: 11.025

2.  High density molecular linkage maps of the tomato and potato genomes.

Authors:  S D Tanksley; M W Ganal; J P Prince; M C de Vicente; M W Bonierbale; P Broun; T M Fulton; J J Giovannoni; S Grandillo; G B Martin
Journal:  Genetics       Date:  1992-12       Impact factor: 4.562

3.  A genetic map of rye chromosome 1R integrating RFLP and cytogenetic loci.

Authors:  M K Wanous; J P Gustafson
Journal:  Theor Appl Genet       Date:  1995-10       Impact factor: 5.699

4.  Isolation and characterization of RAPD-based markers linked to the beet cyst nematode resistance locus (Hs1 (pat-1)) on chromosome 1 of B. patellaris.

Authors:  E M Salentijn; M J Arens-De Reuver; W Lange; T S De Bock; W J Stiekema; R M Klein-Lankhorst
Journal:  Theor Appl Genet       Date:  1995-05       Impact factor: 5.699

5.  Long-range organization of a satellite DNA family flanking the beet cyst nematode resistance locus (Hs1) on chromosome-1 of B. patellaris and B. procumbens.

Authors:  E M Salentijn; N N Sandal; R Klein-Lankhorst; W Lange; T S De Bock; K A Marcker; W J Stiekema
Journal:  Theor Appl Genet       Date:  1994-10       Impact factor: 5.699

6.  Pooled-sampling makes high-resolution mapping practical with DNA markers.

Authors:  G A Churchill; J J Giovannoni; S D Tanksley
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205

Review 7.  Prospects for the genetics of human longevity.

Authors:  F Schächter; D Cohen; T Kirkwood
Journal:  Hum Genet       Date:  1993-07       Impact factor: 4.132

8.  Long-range physical maps of two loci (Aps-1 and GP79) flanking the root-knot nematode resistance gene (Mi) near the centromere of tomato chromosome 6.

Authors:  R A van Daelen; F Gerbens; F van Ruissen; J Aarts; J Hontelez; P Zabel
Journal:  Plant Mol Biol       Date:  1993-10       Impact factor: 4.076

9.  Physical mapping of a region in the soybean (Glycine max) genome containing duplicated sequences.

Authors:  R P Funke; A Kolchinsky; P M Gresshoff
Journal:  Plant Mol Biol       Date:  1993-06       Impact factor: 4.076

Review 10.  Mapping QTLs regulating morpho-physiological traits and yield: case studies, shortcomings and perspectives in drought-stressed maize.

Authors:  Roberto Tuberosa; Silvio Salvi; Maria Corinna Sanguineti; Pierangelo Landi; Marco Maccaferri; Sergio Conti
Journal:  Ann Bot       Date:  2002-06       Impact factor: 4.357
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