Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2.

A variety of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues were synthesized. 2-oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA(2), while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA(2). Copyright (c) 2007 European Peptide Society and John Wiley & Sons, Ltd.