| Literature DB >> 17630734 |
Barbora Bajtos1, Ming Yu, Hongda Zhao, Brian L Pagenkopf.
Abstract
The annulation reaction between various indoles and 2-alkoxycyclopropanoate esters is reported. Both high efficiency and complete stereochemical control were observed in some cases with this annulation process. A single stereocenter on the cyclopropane controls the diastereoselective formation of up to four new stereocenters. A different reaction course was observed with 3-substituted indole substrates, and an intervening C-3 to C-2-migration process arose that gives synthetically useful C-2 alkylation indole products.Entities:
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Year: 2007 PMID： 17630734 DOI： 10.1021/ja067821+
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419