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Literature DB >> 17630506

The role of ubiquitination in the direct mitochondrial death program of p53.

Abstract

p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation. In this review, we will focus on the recently uncovered activating role of ubiquitination in the transcription-independent direct mitochondrial death program of p53.

Entities: Chemical Gene

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Year: 2007 PMID： 17630506 DOI： 10.4161/cc.6.14.4503

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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Cited

39 in total

1. The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein.

Authors: Michela Muscolini; Elisa Montagni; Vanessa Palermo; Silvia Di Agostino; Wei Gu; Salma Abdelmoula-Souissi; Cristina Mazzoni; Giovanni Blandino; Loretta Tuosto
Journal: J Biol Chem Date: 2011-09-27 Impact factor: 5.157

2. Activation of cAMP signaling interferes with stress-induced p53 accumulation in ALL-derived cells by promoting the interaction between p53 and HDM2.

Authors: Elin Hallan Naderi; Aart G Jochemsen; Heidi Kiil Blomhoff; Soheil Naderi
Journal: Neoplasia Date: 2011-07 Impact factor: 5.715

3. MSL2 promotes Mdm2-independent cytoplasmic localization of p53.

Authors: Jan-Philipp Kruse; Wei Gu
Journal: J Biol Chem Date: 2008-11-25 Impact factor: 5.157

4. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.

Authors: J H Jung; S Bae; J Y Lee; S R Woo; H J Cha; Y Yoon; K-S Suh; S-J Lee; I-C Park; Y-W Jin; K-H Lee; S An; J H Lee
Journal: Cell Death Differ Date: 2011-05-20 Impact factor: 15.828

Review 5. Oxygenomics in environmental stress.

Authors: H Sone; H Akanuma; T Fukuda
Journal: Redox Rep Date: 2010 Impact factor: 4.412

The role of ubiquitination in the direct mitochondrial death program of p53.

1. The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein.

2. Activation of cAMP signaling interferes with stress-induced p53 accumulation in ALL-derived cells by promoting the interaction between p53 and HDM2.

3. MSL2 promotes Mdm2-independent cytoplasmic localization of p53.

4. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.

Review 5. Oxygenomics in environmental stress.

6. Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.

Review 7. Mitochondrial determinants of cancer health disparities.

8. Microchip-Based Structure Determination of Disease-Relevant p53.

9. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.

10. p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase.