Literature DB >> 17629291

Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization.

Jennifer Pereira1, Mireille Barlier, Catherine Guillou.   

Abstract

Cyclizations of bicyclic amides via an intramolecular Heck reaction followed by an oxidation reaction generate tricyclic spirocyclohexadienones. From these compounds, tetracyclic ketones can be synthesized to provide useful intermediates for the synthesis of indole alkaloids.

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Year:  2007        PMID： 17629291     DOI： 10.1021/ol0712576

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids.

Authors:  Rahul V Edwankar; Chitra R Edwankar; Ojas A Namjoshi; Jeffrey R Deschamps; James M Cook
Journal:  J Nat Prod       Date:  2012-01-18       Impact factor: 4.050

2.  Crystal structure of 3-meth-oxy-carbonyl-2-(4-meth-oxy-phen-yl)-8-oxo-1-aza-spiro[4.5]deca-1,6,9-trien-1-ium-1-olate.

Authors:  Lucimara Julio Martins; Deborah de Alencar Simoni; Ricardo Aparicio; Fernando Coelho
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-29
  2 in total

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