Literature DB >> 17627580

Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors.

Seiichiro Ogawa1, Miki Kanto, Yoshiyuki Suzuki.   

Abstract

This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-beta-valienamine as a lysosomal beta-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human beta-galactosidase deficiency disorder, G(M1)-gangliosidosis.

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Year:  2007        PMID： 17627580     DOI： 10.2174/138955707781024508

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  7 in total

1.  Novel stereoselective syntheses of N-octyl-β-valienamine (NOV) and N-octyl-4-epi-β-valienamine (NOEV) from (-)-shikimic acid.

Authors:  Feng-Lei Li; Jiang-Ping Yu; Wei Ding; Mian-Mian Sun; Yun-Gang He; Xing-Liang Zhu; Shi-Ling Liu; Xiao-Xin Shi
Journal:  RSC Adv       Date:  2019-12-18       Impact factor: 4.036

2.  Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB.

Authors:  Elizabeth Ficko-Blean; Keith A Stubbs; Oksana Nemirovsky; David J Vocadlo; Alisdair B Boraston
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-28       Impact factor: 11.205

3.  Syntheses and Glycosidase Inhibitory Activities, and in Silico Docking Studies of Pericosine E Analogs Methoxy-Substituted at C6.

Authors:  Yoshihide Usami; Megumi Higuchi; Koji Mizuki; Mizuki Yamamoto; Mao Kanki; Chika Nakasone; Yuya Sugimoto; Makio Shibano; Yoshihiro Uesawa; Junko Nagai; Hiroki Yoneyama; Shinya Harusawa
Journal:  Mar Drugs       Date:  2020-04-20       Impact factor: 5.118

4.  Exploration of Catalytic Selectivity for Aminotransferase (BtrR) Based on Multiple Molecular Dynamics Simulations.

Authors:  Ye Liu; Youzhong Wan; Jingxuan Zhu; Muxin Li; Zhengfei Yu; Jiarui Han; Zuoming Zhang; Weiwei Han
Journal:  Int J Mol Sci       Date:  2019-03-08       Impact factor: 5.923

Review 5.  Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones.

Authors:  Seiichiro Ogawa; Shinichi Kuno; Tatsushi Toyokuni
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2022       Impact factor: 3.945

6.  Synthesis of 6-Halo-Substituted Pericosine A and an Evaluation of Their Antitumor and Antiglycosidase Activities.

Authors:  Yoshihide Usami; Yoshino Mizobuchi; Mai Ijuin; Takeshi Yamada; Mizuki Morita; Koji Mizuki; Hiroki Yoneyama; Shinya Harusawa
Journal:  Mar Drugs       Date:  2022-06-30       Impact factor: 6.085

7.  Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.

Authors:  Yoshiyuki Suzuki; Seiichiro Ogawa; Yasubumi Sakakibara
Journal:  Perspect Medicin Chem       Date:  2009-05-26
  7 in total

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