Literature DB >> 17623685

Comparison of radon lung dosimetry models for the estimation of dose uncertainties.

Renate Winkler-Heil1, Werner Hofmann, James Marsh, Alan Birchall.   

Abstract

In order to investigate the degree of dose uncertainty produced by different models, three dosimetry models were compared with each other, representing different classes of models: (i) The RADEP/IMBA model based on the ICRP Human Respiratory Tract Model, a deterministic regional compartment model, (ii) the RADOS model, a deterministic airway generation model and (iii) the IDEAL dosimetry model, a stochastic airway generation model. The outputs of the three models for defined mining exposure conditions were compared at three different levels: deposition fractions for attached and unattached radon progeny; nuclear transformations, reflecting the combined effect of deposition and clearance; and resulting cellular doses. Resulting dose exposure conversion factors ranged from 7.8 (median) mSv/WLM (IDEAL) to 11.8 mSv/WLM (RADEP/IMBA), with 8.3 mSv/WLM (RADOS) as an intermediate value. Despite methodological and computational differences between the three models, resulting dose conversion factors do not appreciably differ from each other, although predictions by the two generation models are consistently smaller than that for the RADEP/IMBA model.

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Year:  2007        PMID: 17623685     DOI: 10.1093/rpd/ncm339

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  8 in total

1.  Stochastic rat lung dosimetry for inhaled radon progeny: a surrogate for the human lung for lung cancer risk assessment.

Authors:  R Winkler-Heil; M Hussain; W Hofmann
Journal:  Radiat Environ Biophys       Date:  2015-02-28       Impact factor: 1.925

2.  Lung dosimetry of inhaled radon progeny in mice.

Authors:  Akihiro Sakoda; Yuu Ishimori; Kosuke Fukao; Kiyonori Yamaoka; Takahiro Kataoka; Fumihiro Mitsunobu
Journal:  Radiat Environ Biophys       Date:  2012-08-23       Impact factor: 1.925

3.  The conversion of exposures due to radon into the effective dose: the epidemiological approach.

Authors:  T R Beck
Journal:  Radiat Environ Biophys       Date:  2017-09-15       Impact factor: 1.925

4.  Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis.

Authors:  I Zaballa; M Eidemüller
Journal:  Radiat Environ Biophys       Date:  2016-06-22       Impact factor: 1.925

5.  Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro.

Authors:  Eric Chau; Justin F Galloway; Antoinette Nelson; Patrick N Breysse; Denis Wirtz; Peter C Searson; Venkataramana K Sidhaye
Journal:  Nanotoxicology       Date:  2012-08-20       Impact factor: 5.913

6.  Radon transfer from thermal water to human organs in radon therapy: exhalation measurements and model simulations.

Authors:  W Hofmann; R Winkler-Heil; H Lettner; A Hubmer; M Gaisberger
Journal:  Radiat Environ Biophys       Date:  2019-06-29       Impact factor: 1.925

7.  Exposure to Radon and Progeny in a Tourist Cavern.

Authors:  Jeri L Anderson; Leonard M Zwack; Scott E Brueck
Journal:  Health Phys       Date:  2021-06-01       Impact factor: 2.922

8.  The degree of inhomogeneity of the absorbed cell nucleus doses in the bronchial region of the human respiratory tract.

Authors:  Péter Füri; Árpád Farkas; Balázs G Madas; Werner Hofmann; Renate Winkler-Heil; Gábor Kudela; Imre Balásházy
Journal:  Radiat Environ Biophys       Date:  2019-10-05       Impact factor: 1.925

  8 in total

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