AIM: The aim of the study was to assess the cellular and structural properties of skeletal muscle in restless legs syndrome (RLS). METHOD: Twenty patients and 16 controls were included. Aerobic performance was assessed using a submaximal test. On muscle biopsies taken from the tibialis anterior, fiber distribution and fiber area were analyzed together with parameters surveying the microvascularization, especially the tortuosity, which is expressed as a percent of muscle fiber perimeter in contact with the wall of the microvessel, length of capillary/perimeter of fiber (LC/PF) index. RESULTS: The RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (p = 0.01) compared to the controls. CONCLUSION: The higher capillary tortuosity in RLS patients indicates the occurrence of significant remodeling in capillary geometry in RLS. 2007 S. Karger AG, Basel
AIM: The aim of the study was to assess the cellular and structural properties of skeletal muscle in restless legs syndrome (RLS). METHOD: Twenty patients and 16 controls were included. Aerobic performance was assessed using a submaximal test. On muscle biopsies taken from the tibialis anterior, fiber distribution and fiber area were analyzed together with parameters surveying the microvascularization, especially the tortuosity, which is expressed as a percent of muscle fiber perimeter in contact with the wall of the microvessel, length of capillary/perimeter of fiber (LC/PF) index. RESULTS: The RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (p = 0.01) compared to the controls. CONCLUSION: The higher capillary tortuosity in RLS patients indicates the occurrence of significant remodeling in capillary geometry in RLS. 2007 S. Karger AG, Basel
Authors: Christoforos D Giannaki; Giorgos K Sakkas; Christina Karatzaferi; Georgios M Hadjigeorgiou; Eleftherios Lavdas; Vassilios Liakopoulos; Nikolaos Tsianas; Georgios N Koukoulis; Yiannis Koutedakis; Ioannis Stefanidis Journal: PLoS One Date: 2011-10-03 Impact factor: 3.240
Authors: Ulrike H Mitchell; J Daniel Obray; Erik Hunsaker; Brandon T Garcia; Travis J Clarke; Sandra Hope; Scott C Steffensen Journal: Front Neurol Date: 2018-03-15 Impact factor: 4.003