| Literature DB >> 17617692 |
Masato Iwatsuki1, Ryuji Uchida, Yoichi Takakusagi, Atsuko Matsumoto, Cheng-Lin Jiang, Yoko Takahashi, Masayoshi Arai, Susumu Kobayashi, Makoto Matsumoto, Junji Inokoshi, Hiroshi Tomoda, Satoshi Omura.
Abstract
Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus jostii K01-B0171, which was isolated from soil aggregates collected in Yunnan, China. Lariains A and B showed growth inhibition against Mycobacterium smegmatis with MIC values of 3.13 and 6.25 microg/ml in agar dilution method, respectively. Furthermore, lariatin A inhibited the growth of Mycobacterium tuberculosis with an MIC of 0.39 microg/ml in liquid microdilution method.Entities:
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Year: 2007 PMID： 17617692 DOI： 10.1038/ja.2007.48
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649