BACKGROUND:Young children can regulate energy precisely in the short term, showing the potential for an innate compensation mechanism of eating behavior. However, data suggest that precise compensation is attenuated as a function of increasing adiposity, parental feeding style, and age. Common variation in candidate obesity genes may account for some of the individual variation observed in short-term energy compensation. Polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARG) and beta-adrenergic receptor (ADRB3) genes have been linked to increased body mass index (BMI; in kg/m(2)), obesity, and more recently dietary nutrients and preferences. In addition, common variation in ADRB3 interacts with PPARG to modulate adult body weight. OBJECTIVE: This study investigated whether variants in these genes were associated with measurable effects on child eating behavior. DESIGN: Children (n=84) aged 4-10 y were prospectively selected for variants of the PPARG locus (Pro12Ala, C1431T). Heights and weights were measured. Energy intake from a test meal was measured 90 min after ingestion of a no-energy (NE), low-energy (LE), or high-energy (HE) preload, and the compensation index (COMPX) was calculated. RESULTS:BMI differed significantly by gene model, whereby Pro12Ala was associated with a lower BMI. Poor COMPX was associated with the PPARG T1431 allele (P=0.009). There was a significant interaction between COMPX and the ADRB3 Trp64Arg variant in modulating compensation (P=0.003), whereas the Arg64 allele was associated with good compensation (P=0.001). CONCLUSIONS: This is the first study to suggest that a genetic interaction involving ADRB3 and PPARG variants influences eating behavior in children.
RCT Entities:
BACKGROUND: Young children can regulate energy precisely in the short term, showing the potential for an innate compensation mechanism of eating behavior. However, data suggest that precise compensation is attenuated as a function of increasing adiposity, parental feeding style, and age. Common variation in candidate obesity genes may account for some of the individual variation observed in short-term energy compensation. Polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARG) and beta-adrenergic receptor (ADRB3) genes have been linked to increased body mass index (BMI; in kg/m(2)), obesity, and more recently dietary nutrients and preferences. In addition, common variation in ADRB3 interacts with PPARG to modulate adult body weight. OBJECTIVE: This study investigated whether variants in these genes were associated with measurable effects on child eating behavior. DESIGN:Children (n=84) aged 4-10 y were prospectively selected for variants of the PPARG locus (Pro12Ala, C1431T). Heights and weights were measured. Energy intake from a test meal was measured 90 min after ingestion of a no-energy (NE), low-energy (LE), or high-energy (HE) preload, and the compensation index (COMPX) was calculated. RESULTS: BMI differed significantly by gene model, whereby Pro12Ala was associated with a lower BMI. Poor COMPX was associated with the PPARG T1431 allele (P=0.009). There was a significant interaction between COMPX and the ADRB3Trp64Arg variant in modulating compensation (P=0.003), whereas the Arg64 allele was associated with good compensation (P=0.001). CONCLUSIONS: This is the first study to suggest that a genetic interaction involving ADRB3 and PPARG variants influences eating behavior in children.
Authors: Todd L Edwards; Digna R Velez Edwards; Raquel Villegas; Sarah S Cohen; Maciej S Buchowski; Jay H Fowke; David Schlundt; Jirong Long; Ji Rong Long; Qiuyin Cai; Wei Zheng; Xiao-Ou Shu; Margaret K Hargreaves; Jeffrey Smith; Smith Jeffrey; Scott M Williams; Lisa B Signorello; William J Blot; Charles E Matthews Journal: Am J Epidemiol Date: 2011-11-20 Impact factor: 4.897
Authors: Tanja V E Kral; David B Allison; Leann L Birch; Virginia A Stallings; Reneé H Moore; Myles S Faith Journal: Am J Clin Nutr Date: 2012-08-01 Impact factor: 7.045
Authors: Penny Gordon-Larsen; John E French; Naima Moustaid-Moussa; Venkata S Voruganti; Elizabeth J Mayer-Davis; Christopher A Bizon; Zhiyong Cheng; Delisha A Stewart; John W Easterbrook; Saame Raza Shaikh Journal: Adv Nutr Date: 2021-10-01 Impact factor: 11.567
Authors: Laura J Corbin; Vanessa Y Tan; David A Hughes; Kaitlin H Wade; Dirk S Paul; Katherine E Tansey; Frances Butcher; Frank Dudbridge; Joanna M Howson; Momodou W Jallow; Catherine John; Nathalie Kingston; Cecilia M Lindgren; Michael O'Donavan; Stephen O'Rahilly; Michael J Owen; Colin N A Palmer; Ewan R Pearson; Robert A Scott; David A van Heel; John Whittaker; Tim Frayling; Martin D Tobin; Louise V Wain; George Davey Smith; David M Evans; Fredrik Karpe; Mark I McCarthy; John Danesh; Paul W Franks; Nicholas J Timpson Journal: Nat Commun Date: 2018-02-19 Impact factor: 14.919