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Literature DB >> 17616595

The las enzymes control pyruvate metabolism in Lactococcus lactis during growth on maltose.

Christian Solem¹, Brian Koebmann, Fen Yang, Peter R Jensen.

Abstract

The fermentation pattern of Lactococcus lactis with altered activities of the las enzymes was examined on maltose. The wild type converted 65% of the maltose to mixed acids. An increase in phosphofructokinase or lactate dehydrogenase expression shifted the fermentation towards homolactic fermentation, and with a high level of expression of the las operon the fermentation was homolactic.

Entities: Chemical Species

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Year: 2007 PMID： 17616595 PMCID： PMC2045170 DOI： 10.1128/JB.00902-07

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

19 in total

1. Modulation of gene expression made easy.

Authors: Christian Solem; Peter Ruhdal Jensen
Journal: Appl Environ Microbiol Date: 2002-05 Impact factor: 4.792

2. Twofold reduction of phosphofructokinase activity in Lactococcus lactis results in strong decreases in growth rate and in glycolytic flux.

Authors: H W Andersen; C Solem; K Hammer; P R Jensen
Journal: J Bacteriol Date: 2001-06 Impact factor: 3.490

3. Expression of genes encoding F(1)-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis.

Authors: Brian J Koebmann; Christian Solem; Martin B Pedersen; Dan Nilsson; Peter R Jensen
Journal: Appl Environ Microbiol Date: 2002-09 Impact factor: 4.792

4. Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis.

Authors: Brian Koebmann; Christian Solem; Peter Ruhdal Jensen
Journal: FEBS J Date: 2005-05 Impact factor: 5.542

5. Lactate dehydrogenase has no control on lactate production but has a strong negative control on formate production in Lactococcus lactis.

Authors: H W Andersen; M B Pedersen; K Hammer; P R Jensen
Journal: Eur J Biochem Date: 2001-12

6. Fructose 1,6-diphosphate-activated L-lactate dehydrogenase from Streptococcus lactis: kinetic properties and factors affecting activation.

Authors: V L Crow; G G Pritchard
Journal: J Bacteriol Date: 1977-07 Impact factor: 3.490

7. Improved medium for lactic streptococci and their bacteriophages.

Authors: B E Terzaghi; W E Sandine
Journal: Appl Microbiol Date: 1975-06

8. Reappraisal of the regulation of lactococcal L-lactate dehydrogenase.

Authors: Ed W J van Niel; Johan Palmfeldt; Rani Martin; Marco Paese; Bärbel Hahn-Hägerdal
Journal: Appl Environ Microbiol Date: 2004-03 Impact factor: 4.792

9. Identification of a novel operon in Lactococcus lactis encoding three enzymes for lactic acid synthesis: phosphofructokinase, pyruvate kinase, and lactate dehydrogenase.

Authors: R M Llanos; C J Harris; A J Hillier; B E Davidson
Journal: J Bacteriol Date: 1993-05 Impact factor: 3.490

10. Use of the integration elements encoded by the temperate lactococcal bacteriophage TP901-1 to obtain chromosomal single-copy transcriptional fusions in Lactococcus lactis.

Authors: L Brøndsted; K Hammer
Journal: Appl Environ Microbiol Date: 1999-02 Impact factor: 4.792

12 in total

1. Characterization of three lactic acid bacteria and their isogenic ldh deletion mutants shows optimization for YATP (cell mass produced per mole of ATP) at their physiological pHs.

Authors: Tomas Fiedler; Martijn Bekker; Maria Jonsson; Ibrahim Mehmeti; Anja Pritzschke; Nikolai Siemens; Ingolf Nes; Jeroen Hugenholtz; Bernd Kreikemeyer
Journal: Appl Environ Microbiol Date: 2010-11-19 Impact factor: 4.792

The las enzymes control pyruvate metabolism in Lactococcus lactis during growth on maltose.

1. Modulation of gene expression made easy.

2. Twofold reduction of phosphofructokinase activity in Lactococcus lactis results in strong decreases in growth rate and in glycolytic flux.

3. Expression of genes encoding F(1)-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis.

4. Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis.

5. Lactate dehydrogenase has no control on lactate production but has a strong negative control on formate production in Lactococcus lactis.

6. Fructose 1,6-diphosphate-activated L-lactate dehydrogenase from Streptococcus lactis: kinetic properties and factors affecting activation.

7. Improved medium for lactic streptococci and their bacteriophages.

8. Reappraisal of the regulation of lactococcal L-lactate dehydrogenase.

9. Identification of a novel operon in Lactococcus lactis encoding three enzymes for lactic acid synthesis: phosphofructokinase, pyruvate kinase, and lactate dehydrogenase.

10. Use of the integration elements encoded by the temperate lactococcal bacteriophage TP901-1 to obtain chromosomal single-copy transcriptional fusions in Lactococcus lactis.

1. Characterization of three lactic acid bacteria and their isogenic ldh deletion mutants shows optimization for YATP (cell mass produced per mole of ATP) at their physiological pHs.

2. The MG1363 and IL1403 laboratory strains of Lactococcus lactis and several dairy strains are diploid.

3. Molecular and metabolic adaptations of Lactococcus lactis at near-zero growth rates.

4. Effects of Glucose and Starch on Lactate Production by Newly Isolated Streptococcus bovis S1 from Saanen Goats.

5. Towards enhanced galactose utilization by Lactococcus lactis.

6. Monte-Carlo modeling of the central carbon metabolism of Lactococcus lactis: insights into metabolic regulation.

7. Searching for principles of microbial physiology.

8. Acetate kinase isozymes confer robustness in acetate metabolism.

9. Characterization of Context-Dependent Effects on Synthetic Promoters.

Review 10. Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.