Literature DB >> 17615675

Cytotoxic constituents from angelicae sinensis radix.

Quan Cheng Chen1, JongPill Lee, WenYi Jin, UiJoung Youn, HongJin Kim, Ik Soo Lee, XinFeng Zhang, KyungSik Song, YeonHee Seong, KiHwan Bae.   

Abstract

Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z, 17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 +/- 0.10 and 4.78 +/- 0.18 microM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 +/- 0.19 and 9.87 +/- 0.14 microM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 +/- 0.90 and 2.87 +/- 0.49 microM, respectively.

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Year:  2007        PMID： 17615675     DOI： 10.1007/bf02977650

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  10 in total

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2.  Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein.

Authors:  Chang Chen; Chuanhong Wu; Xinhua Lu; Zhiyong Yan; Jian Gao; Hui Zhao; Shaojing Li
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Review 3.  Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

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Journal:  J Tradit Complement Med       Date:  2012-01

4.  The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors.

Authors:  Yu-Ling Lin; Wen-Lin Lai; Horng-Jyh Harn; Pei-Hsiu Hung; Ming-Chang Hsieh; Kai-Fu Chang; Xiao-Fan Huang; Kuang-Wen Liao; Ming-Shih Lee; Nu-Man Tsai
Journal:  Evid Based Complement Alternat Med       Date:  2013-11-10       Impact factor: 2.629

5.  The effect of tou nong san on transplanted tumor growth in nude mice.

Authors:  Liang-Hua Fang; Rui-Ping Wang; Shou-You Hu; Yu-Hao Teng; Wei-Bing Xie
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6.  Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.

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Review 7.  Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms.

Authors:  Rocco Giordano; Zeinab Saii; Malthe Fredsgaard; Laura Sini Sofia Hulkko; Thomas Bouet Guldbæk Poulsen; Mikkel Eggert Thomsen; Nanna Henneberg; Silvana Maria Zucolotto; Lars Arendt-Nielsen; Jutta Papenbrock; Mette Hedegaard Thomsen; Allan Stensballe
Journal:  Molecules       Date:  2021-05-24       Impact factor: 4.411

8.  Inhibitory effect of herbal remedy PERVIVO and anti-inflammatory drug sulindac on L-1 sarcoma tumor growth and tumor angiogenesis in Balb/c mice.

Authors:  P Skopiński; B J Bałan; J Kocik; R Zdanowski; S Lewicki; M Niemcewicz; K Gawrychowski; E Skopińska-Różewska; W Stankiewicz
Journal:  Mediators Inflamm       Date:  2013-06-27       Impact factor: 4.711

9.  Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages.

Authors:  Hongyi Qi; Zhuyun Jiang; Chengqiang Wang; Yi Yang; Li Li; Hui He; Zanyang Yu
Journal:  Oncotarget       Date:  2017-04-25

Review 10.  Bioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development.

Authors:  Lars Porskjær Christensen
Journal:  Molecules       Date:  2020-05-31       Impact factor: 4.411
  10 in total

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