Rituparna Maiti1, N K Agrawal, D Dash, B L Pandey. 1. Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, India. rituparnamaiti@rediffmail.com
Abstract
OBJECTIVES:Inflammation and oxidative stress are main culprits behind atherosclerosis in diabetes mellitus. This study explores the effect of add-on Pentoxifylline on inflammatory burden and oxidative stress in hypertensive diabetic patients. RESEARCH DESIGN AND METHODS: 60 hypertensive type 2diabetic, aged > or = 45 years were evaluated for anthropometry, clinical parameters, C-reactive protein, total leukocyte count, erythrocyte sedimentation rate, serum albumin, plasma malondialdehyde, blood reduced glutathione, platelet aggregation and clot retraction profile. With informed consent and randomization, Pentoxifylline (400 mg) was prescribed to 30 patients orally twice daily with meals as add-on therapy to the standard therapeutic regimen for one month. The particular parameters were repeated in 26 patients in control group and 25 patients inPentoxifylline group who completed the follow up. The study was a randomized, open, add-on clinical trial with parallel controls. RESULTS: At one-month follow-up, in the Pentoxifylline group, there was 20.9% decrease (p<0.001) in C-reactive protein, 18% reduction (p<0.001) in erythrocyte sedimentation rate, 11.1% reduction (p<0.001) in total leukocyte count and 5.8% increase (p=0.003) in serum albumin. Pentoxifylline showed 20.2% reduction in plasma malondialdehyde and 4.6% increase in blood reduced glutathione level. In therapeutic dose range, Pentoxifylline exerted a significant anti-aggregatory effect and a dose dependent decrease in clot retraction in-vitro but there was no significant change in ex-vivo clot retraction. The control group showed no statistically significant change in parameters assessed. CONCLUSION: This study reveals improvements in inflammatory markers, oxidative stress and platelet-aggregation by Pentoxifylline, thus preventing atherosclerosis in diabetes mellitus.
RCT Entities:
OBJECTIVES: Inflammation and oxidative stress are main culprits behind atherosclerosis in diabetes mellitus. This study explores the effect of add-on Pentoxifylline on inflammatory burden and oxidative stress in hypertensive diabeticpatients. RESEARCH DESIGN AND METHODS: 60 hypertensive type 2 diabetic, aged > or = 45 years were evaluated for anthropometry, clinical parameters, C-reactive protein, total leukocyte count, erythrocyte sedimentation rate, serum albumin, plasma malondialdehyde, blood reduced glutathione, platelet aggregation and clot retraction profile. With informed consent and randomization, Pentoxifylline (400 mg) was prescribed to 30 patients orally twice daily with meals as add-on therapy to the standard therapeutic regimen for one month. The particular parameters were repeated in 26 patients in control group and 25 patients in Pentoxifylline group who completed the follow up. The study was a randomized, open, add-on clinical trial with parallel controls. RESULTS: At one-month follow-up, in the Pentoxifylline group, there was 20.9% decrease (p<0.001) in C-reactive protein, 18% reduction (p<0.001) in erythrocyte sedimentation rate, 11.1% reduction (p<0.001) in total leukocyte count and 5.8% increase (p=0.003) in serum albumin. Pentoxifylline showed 20.2% reduction in plasma malondialdehyde and 4.6% increase in blood reduced glutathione level. In therapeutic dose range, Pentoxifylline exerted a significant anti-aggregatory effect and a dose dependent decrease in clot retraction in-vitro but there was no significant change in ex-vivo clot retraction. The control group showed no statistically significant change in parameters assessed. CONCLUSION: This study reveals improvements in inflammatory markers, oxidative stress and platelet-aggregation by Pentoxifylline, thus preventing atherosclerosis in diabetes mellitus.
Authors: Jessica Santana de Oliveira; Alluanan Adelson do Nascimento Silva; Fernanda Carolina Ribeiro Dias; Elizabeth Lopes de Oliveira; Emanuel Felipe de Oliveira Filho; Pierre Castro Soares; Catarina Michelle de Oliveira Ferreira; Valdemiro Amaro da Silva Junior Journal: Int J Exp Pathol Date: 2022-06-23 Impact factor: 2.793
Authors: Juan F Navarro-González; Carmen Mora-Fernández; Mercedes Muros de Fuentes; Jesús Chahin; María L Méndez; Eduardo Gallego; Manuel Macía; Nieves del Castillo; Antonio Rivero; María A Getino; Patricia García; Ana Jarque; Javier García Journal: J Am Soc Nephrol Date: 2014-06-26 Impact factor: 10.121