Literature DB >> 17612932

Beclin 1 mRNA strongly correlates with Bcl-XLmRNA expression in human hepatocellular carcinoma.

F Daniel1, A Legrand, D Pessayre, F Borrega-Pires, L Mbida, B Lardeux, C Degott, J Tran van Nhieu, D Bernuau.   

Abstract

Beclin 1 physically associates with Bcl-x(L) and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-X(L) mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-X(L) expression in HCC may suggest cooperation in the regulation of apoptosis.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17612932     DOI： 10.1080/07357900701206323

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  8 in total

Review 1.  Biological determinants of radioresistance and their remediation in pancreatic cancer.

Authors:  Parthasarathy Seshacharyulu; Michael J Baine; Joshua J Souchek; Melanie Menning; Sukhwinder Kaur; Ying Yan; Michel M Ouellette; Maneesh Jain; Chi Lin; Surinder K Batra
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-02-27       Impact factor: 10.680

2.  Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells.

Authors:  Ki-Hwan Eum; Michael Lee
Journal:  Mol Cells       Date:  2011-01-21       Impact factor: 5.034

Review 3.  Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer.

Authors:  Kevin N Dalby; Ibrahim Tekedereli; Gabriel Lopez-Berestein; Bulent Ozpolat
Journal:  Autophagy       Date:  2010-04-26       Impact factor: 16.016

4.  Low expression of MAP1LC3B, associated with low Beclin-1, predicts lymph node metastasis and poor prognosis of gastric cancer.

Authors:  Shuangjin Yu; Guanghua Li; Zhao Wang; Zhixiong Wang; Chuangqi Chen; Shirong Cai; Yulong He
Journal:  Tumour Biol       Date:  2016-09-22

Review 5.  Molecular pathways: autophagy in cancer--a matter of timing and context.

Authors:  Michelle Cicchini; Vassiliki Karantza; Bing Xia
Journal:  Clin Cancer Res       Date:  2014-08-27       Impact factor: 12.531

6.  Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer.

Authors:  Qi-Rong Geng; Da-Zhi Xu; Long-Jun He; Jia-Bing Lu; Zhi-Wei Zhou; You-Qing Zhan; Yue Lu
Journal:  PLoS One       Date:  2012-09-27       Impact factor: 3.240

Review 7.  Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer.

Authors:  N Hasima; B Ozpolat
Journal:  Cell Death Dis       Date:  2014-11-06       Impact factor: 8.469

8.  Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma.

Authors:  Andromachi Kotsafti; Fabio Farinati; Romilda Cardin; Umberto Cillo; Donato Nitti; Marina Bortolami
Journal:  BMC Gastroenterol       Date:  2012-08-28       Impact factor: 3.067
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.