Literature DB >> 17611486

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts.

Haipeng Cheng1, Kulandaivelu S Vetrivel, Ping Gong, Xavier Meckler, Angèle Parent, Gopal Thinakaran.   

Abstract

Alzheimer's disease (AD) is the most common cause of age-related dementia. Pathologically, AD is characterized by the deposition in the brain of amyloid-beta peptides derived from proteolysis of amyloid precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) and gamma-secretase. A growing body of evidence implicates cholesterol and cholesterol-rich membrane microdomains in amyloidogenic processing of APP. Here, we review recent findings regarding the association of BACE1, gamma-secretase and APP in lipid rafts, and discuss potential therapeutic strategies for AD that are based on knowledge gleaned from the membrane environment that fosters APP processing.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17611486      PMCID： PMC2880530          DOI： 10.1038/ncpneuro0549

Source DB:  PubMed          Journal:  Nat Clin Pract Neurol        ISSN： 1745-834X


  58 in total

Review 1.  Palmitoylation of intracellular signaling proteins: regulation and function.

Authors:  Jessica E Smotrys; Maurine E Linder
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

2.  Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

Authors:  E H Koo; S S Sisodia; D R Archer; L J Martin; A Weidemann; K Beyreuther; P Fischer; C L Masters; D L Price
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

3.  Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.

Authors:  D L Sparks; S W Scheff; J C Hunsaker; H Liu; T Landers; D R Gross
Journal:  Exp Neurol       Date:  1994-03       Impact factor: 5.330

4.  Evidence that production and release of amyloid beta-protein involves the endocytic pathway.

Authors:  E H Koo; S L Squazzo
Journal:  J Biol Chem       Date:  1994-07-01       Impact factor: 5.157

5.  Beta-amyloid precursor protein cleavage by a membrane-bound protease.

Authors:  S S Sisodia
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

6.  Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

Authors:  Kulandaivelu S Vetrivel; Haipeng Cheng; William Lin; Takashi Sakurai; Tong Li; Nobuyuki Nukina; Philip C Wong; Huaxi Xu; Gopal Thinakaran
Journal:  J Biol Chem       Date:  2004-08-17       Impact factor: 5.157

Review 7.  The gamma-secretase complex: machinery for intramembrane proteolysis.

Authors:  Takeshi Iwatsubo
Journal:  Curr Opin Neurobiol       Date:  2004-06       Impact factor: 6.627

8.  Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.

Authors:  Mingming Hao; Sushmita Mukherjee; Yu Sun; Frederick R Maxfield
Journal:  J Biol Chem       Date:  2004-01-20       Impact factor: 5.157

9.  Modulation of amyloid precursor protein cleavage by cellular sphingolipids.

Authors:  Naoya Sawamura; Mihee Ko; Wenxin Yu; Kun Zou; Kentaro Hanada; Toshiharu Suzuki; Jian-Sheng Gong; Katsuhiko Yanagisawa; Makoto Michikawa
Journal:  J Biol Chem       Date:  2004-01-10       Impact factor: 5.157

Review 10.  BACE1: the beta-secretase enzyme in Alzheimer's disease.

Authors:  Robert Vassar
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444
View more
  42 in total

Review 1.  An overview of APP processing enzymes and products.

Authors:  Vivian W Chow; Mark P Mattson; Philip C Wong; Marc Gleichmann
Journal:  Neuromolecular Med       Date:  2010-03       Impact factor: 3.843

2.  Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.

Authors:  Carole Deyts; Kulandaivelu S Vetrivel; Shibandri Das; Yumiko M Shepherd; Denis J Dupré; Gopal Thinakaran; Angèle T Parent
Journal:  J Neurosci       Date:  2012-02-01       Impact factor: 6.167

3.  Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing.

Authors:  Xiaoguang Yang; Wenwen Sheng; Grace Y Sun; James C-M Lee
Journal:  Neurochem Int       Date:  2010-12-22       Impact factor: 3.921

Review 4.  Substrate specificity of gamma-secretase and other intramembrane proteases.

Authors:  A J Beel; C R Sanders
Journal:  Cell Mol Life Sci       Date:  2008-05       Impact factor: 9.261

5.  Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.

Authors:  Y Wang; V Buggia-Prévot; M E Zavorka; R C Bleackley; R G MacDonald; G Thinakaran; S Kar
Journal:  Mol Cell Biol       Date:  2015-05-04       Impact factor: 4.272

Review 6.  Subcellular targeting strategies for drug design and delivery.

Authors:  Lawrence Rajendran; Hans-Joachim Knölker; Kai Simons
Journal:  Nat Rev Drug Discov       Date:  2010-01       Impact factor: 84.694

7.  Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer's disease patients.

Authors:  Alana C Costa; Helena P G Joaquim; Valéria S Nunes; Daniel S Kerr; Guilherme S Ferreira; Orestes V Forlenza; Wagner F Gattaz; Leda Leme Talib
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2017-08-31       Impact factor: 5.270

8.  Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Authors:  Kulandaivelu S Vetrivel; Xavier Meckler; Ying Chen; Phuong D Nguyen; Nabil G Seidah; Robert Vassar; Philip C Wong; Masaki Fukata; Maria Z Kounnas; Gopal Thinakaran
Journal:  J Biol Chem       Date:  2008-12-12       Impact factor: 5.157

Review 9.  Cellular membrane fluidity in amyloid precursor protein processing.

Authors:  Xiaoguang Yang; Grace Y Sun; Gunter P Eckert; James C-M Lee
Journal:  Mol Neurobiol       Date:  2014-02-20       Impact factor: 5.590

10.  Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.

Authors:  Kulandaivelu S Vetrivel; Xulun Zhang; Xavier Meckler; Haipeng Cheng; Sungho Lee; Ping Gong; Kryslaine O Lopes; Ying Chen; Nobuhisa Iwata; Ke-Jie Yin; Jin-Moo Lee; Angèle T Parent; Takaomi C Saido; Yue-Ming Li; Sangram S Sisodia; Gopal Thinakaran
Journal:  J Biol Chem       Date:  2008-05-01       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.