Literature DB >> 17609854

Bioluminescent imaging of hepatocellular carcinoma in live mice.

Yi Wang1, Zhidong Sun, Jianchun Peng, Linsheng Zhan.   

Abstract

A non-invasive orthotopic hepatocellular carcinoma (HCC) model was created with human HCC cells (HepG-Luc) constitutively expressing luciferase (Luc) in nude mice. Development of tumor growth and response to anti-tumor therapy combined with 5-fluorouracil and cisplatin was monitored by whole-body bioluminescent imaging (BLI). Luciferase activity in the tumor, determined by BLI, correlated with the tumor volume and weight. The anti-tumor therapy proved effective by BLI monitoring. In conclusion, BLI by luciferase provides a non-invasive method of monitoring tumor activities that can prove useful for therapeutic intervention studies.

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Year:  2007        PMID： 17609854     DOI： 10.1007/s10529-007-9452-0

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  9 in total

Review 1.  Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies.

Authors:  Vishnu M Chandra; Luke R Wilkins; David L Brautigan
Journal:  Radiol Imaging Cancer       Date:  2022-07

2.  In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma.

Authors:  W Maes; C Deroose; V Reumers; O Krylyshkina; R Gijsbers; V Baekelandt; J Ceuppens; Z Debyser; S W Van Gool
Journal:  J Neurooncol       Date:  2008-09-12       Impact factor: 4.130

3.  Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice.

Authors:  Brian A Neff; Stephen G Voss; Cory Allen; Mark A Schroeder; Colin L W Driscoll; Michael J Link; Evanthia Galanis; Jann N Sarkaria
Journal:  Otol Neurotol       Date:  2009-01       Impact factor: 2.311

4.  Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI.

Authors:  Dawen Zhao; Edmond Richer; Peter P Antich; Ralph P Mason
Journal:  FASEB J       Date:  2008-02-08       Impact factor: 5.191

5.  Intravenous KITENIN shRNA injection suppresses hepatic metastasis and recurrence of colon cancer in an orthotopic mouse model.

Authors:  Jun-Eul Hwang; Hyun-Jeong Shim; Young-Kyu Park; Sang-Hee Cho; Woo-Kyun Bae; Dae-Eun Kim; Kyung-Keun Kim; Ik-Joo Chung
Journal:  J Korean Med Sci       Date:  2011-10-27       Impact factor: 2.153

6.  Development of a High-Throughput Molecular Imaging-Based Orthotopic Hepatocellular Carcinoma Model.

Authors:  Gloria L Hwang; Maurice A van den Bosch; Young I Kim; Regina Katzenberg; Juergen K Willmann; Ramasamy Paulmurugan; Sanjiv S Gambhir; Lawrence Hofmann
Journal:  Cureus       Date:  2015-06-27

7.  Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Authors:  Kevin J Kauffman; Matthias A Oberli; J Robert Dorkin; Juan E Hurtado; James C Kaczmarek; Shivani Bhadani; Jeff Wyckoff; Robert Langer; Ana Jaklenec; Daniel G Anderson
Journal:  Mol Ther Nucleic Acids       Date:  2017-11-21       Impact factor: 8.886

8.  Genetic modification of cancer cells using non-viral, episomal S/MAR vectors for in vivo tumour modelling.

Authors:  Orestis Argyros; Suet Ping Wong; Kate Gowers; Richard Paul Harbottle
Journal:  PLoS One       Date:  2012-10-26       Impact factor: 3.240

9.  Efficacy assessment of sustained intraperitoneal paclitaxel therapy in a murine model of ovarian cancer using bioluminescent imaging.

Authors:  V Vassileva; E H Moriyama; R De Souza; J Grant; C J Allen; B C Wilson; M Piquette-Miller
Journal:  Br J Cancer       Date:  2008-11-25       Impact factor: 7.640
  9 in total

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