| Literature DB >> 17609118 |
V Andreoli1, R Cittadella, P Valentino, F Condino, A La Russa, M Liguori, I Manna, P Spadafora, R Nisticò, D Pirritano, A Clodomiro, A Quattrone.
Abstract
Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy.Entities:
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Year: 2007 PMID： 17609118 DOI： 10.1016/j.jneuroim.2007.06.015
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478