Literature DB >> 17608533

Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia.

Siew-Huah Lim1, Kooi-Mow Sim, Zanariah Abdullah, Osamu Hiraku, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam.   

Abstract

Four new indole alkaloids were obtained from two Kopsia species, 6-oxoleuconoxine (1) from the leaf extract of K. griffithii and kopsinitarine E (2), kopsijasminine (3), and kopsonoline (4) from the stem-bark extract of K. teoi. The structures of these alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells.

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Year:  2007        PMID： 17608533     DOI： 10.1021/np0701778

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  1,4-Diazaspiro[2.2]pentanes as a flexible platform for the synthesis of diamine-bearing stereotriads.

Authors:  Jared W Rigoli; Luke A Boralsky; John C Hershberger; Dagmara Marston; Alan R Meis; Ilia A Guzei; Jennifer M Schomaker
Journal:  J Org Chem       Date:  2012-02-14       Impact factor: 4.354

2.  Proline Sulfonamide-Based Organocatalysis: Better Late than Never.

Authors:  Hua Yang; Rich G Carter
Journal:  Synlett       Date:  2010-09-01       Impact factor: 2.454

Review 3.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036

Review 4.  Recent metal-catalysed approaches for the synthesis of cyclopenta[b]indoles.

Authors:  Thavaraj Vivekanand; Bishnupada Satpathi; Siddheshwar K Bankar; S S V Ramasastry
Journal:  RSC Adv       Date:  2018-05-22       Impact factor: 4.036

Review 5.  Recent Advances in the Synthesis of β-Carboline Alkaloids.

Authors:  Tímea Szabó; Balázs Volk; Mátyás Milen
Journal:  Molecules       Date:  2021-01-27       Impact factor: 4.411

Review 6.  Samarium(ii) iodide-mediated reactions applied to natural product total synthesis.

Authors:  Majid M Heravi; Azadeh Nazari
Journal:  RSC Adv       Date:  2022-03-30       Impact factor: 3.361

Review 7.  A comprehensive review on phytochemistry and pharmacology of genus Kopsia: monoterpene alkaloids - major secondary metabolites.

Authors:  Nguyen Quang Hop; Ninh The Son
Journal:  RSC Adv       Date:  2022-07-05       Impact factor: 4.036
  7 in total

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