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Literature DB >> 17608433

De novo formal synthesis of (-)-virginiamycin M2 via the asymmetric hydration of dienoates.

Matthew S Mortensen¹, Joshua M Osbourn, George A O'Doherty.

Abstract

A de novo approach to the formal total synthesis of the macrolide natural product (-)-virginiamycin M2 has been achieved via a convergent approach. The absolute and relative stereochemistry of the nonpeptide portion of (-)-virginiamycin M2 was introduced by two Sharpless asymmetric dihydroxylation reactions.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17608433 PMCID： PMC2527507 DOI： 10.1021/ol071145e

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

19 in total

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9. Solvent affects the conformation of virginiamycin M1 (pristinamycin IIA, streptogramin A).

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