| Literature DB >> 16901173 |
Md Moinuddin Ahmed1, Hu Cui, George A O'Doherty.
Abstract
A short and highly efficient route to both enantiomers of muricatacin as well as the C-5-epimer has been developed. The key to the overall transformation is the highly regio- and enantioselective Sharpless asymmetric dihydroxylation of an (E,Z)-dienoate. The highly efficient stereoselective synthesis prepares (-)-muricatacin in seven steps and 66% overall yield.Entities:
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Year: 2006 PMID： 16901173 DOI： 10.1021/jo061057s
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354