Literature DB >> 17605042

Uncomplicated outcome after an accidental overdose of nevirapine in a newborn.

Jean-François Brasme1, Frédéric Mille, Mounir Benhayoun, Françoise Bavoux, Albert Faye, Natacha Teissier, Eric Lachassinne, Stéphane Dauger.   

Abstract

We report the first case of a massive accidental overdose of nevirapine in a 1-week newborn, due to confusion between nevirapine (Viramune) and nelfinavir (Viracept). The drug was eliminated spontaneously and quickly. We only observed mild neutropenia and hyperlactatemia, which regressed on its own without any clinical complication. Despite the good evolution of this massive overdose, physicians should be aware of confusion risks between some antiretroviral drugs.

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Year:  2007        PMID： 17605042     DOI： 10.1007/s00431-007-0541-9

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.860


  7 in total

1.  Pharmacological implications of lengthened in-utero exposure to nevirapine.

Authors:  G P Taylor; E G Lyall; D Back; C Ward; G Tudor-Williams
Journal:  Lancet       Date:  2000-06-17       Impact factor: 79.321

2.  Similarity as a risk factor in drug-name confusion errors: the look-alike (orthographic) and sound-alike (phonetic) model.

Authors:  B L Lambert; S J Lin; K Y Chang; S K Gandhi
Journal:  Med Care       Date:  1999-12       Impact factor: 2.983

Review 3.  Population clinical pharmacology of children: modelling covariate effects.

Authors:  Brian J Anderson; Karel Allegaert; Nicholas H G Holford
Journal:  Eur J Pediatr       Date:  2006-06-29       Impact factor: 3.183

4.  Confusion of nelfinavir and nevirapine.

Authors:  B Max; N Mourikes
Journal:  N Engl J Med       Date:  1998-02-05       Impact factor: 91.245

5.  Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat.

Authors:  Jacintha M Shenton; Marija Popovic; Jie Chen; Mary Jane Masson; Jack P Uetrecht
Journal:  Chem Res Toxicol       Date:  2005-12       Impact factor: 3.739

6.  Are adverse events of nevirapine and efavirenz related to plasma concentrations?

Authors:  Bregt S Kappelhoff; Frank van Leth; Patrick A Robinson; Thomas R MacGregor; Ezio Baraldi; Francesco Montella; David E Uip; Melanie A Thompson; Darren B Russell; Joep M A Lange; Jos H Beijnen; Alwin D R Huitema
Journal:  Antivir Ther       Date:  2005

7.  Pharmacokinetics, safety, and activity of nevirapine in human immunodeficiency virus type 1-infected children.

Authors:  K Luzuriaga; Y Bryson; G McSherry; J Robinson; B Stechenberg; G Scott; M Lamson; S Cort; J L Sullivan
Journal:  J Infect Dis       Date:  1996-10       Impact factor: 5.226
  7 in total
  1 in total

Review 1.  A review of the toxicity of HIV medications.

Authors:  Asa M Margolis; Harry Heverling; Paul A Pham; Andrew Stolbach
Journal:  J Med Toxicol       Date:  2014-03
  1 in total

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