Wenbin Liang1. 1. School of Public Health, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia. wenbin.liang@postgrad.curtin.edu.au
Abstract
AIM: To investigate the interaction effects of age and sex on the risk of grade-specific second primary colorectal cancer (SPCRC). METHOD: This is a retrospective cohort study, using registry data covering the period 1973-2003 from the SEER program, National Cancer Institute. The sex-age-specific incidence rates of Grade 1, Grade 2 and Grade 3 second primary colorectal cancer (SPCRC) were calculated. Poisson regression models were used to estimate the interaction effects between sex and age. RESULTS: The sex-age-specific incidence rates of Grade 1, Grade 2, and Grade 3 second primary colorectal cancer (SPCRC) increased gradually with age, especially in females. There was a significant interaction effect between sex and age on the risk of Grade 3 second primary colon cancer. CONCLUSION: Decrease in female hormone level since menopausal age may increase the risk of a second primary colon cancer, especially a cancer with poorer differentiation.
AIM: To investigate the interaction effects of age and sex on the risk of grade-specific second primary colorectal cancer (SPCRC). METHOD: This is a retrospective cohort study, using registry data covering the period 1973-2003 from the SEER program, National Cancer Institute. The sex-age-specific incidence rates of Grade 1, Grade 2 and Grade 3 second primary colorectal cancer (SPCRC) were calculated. Poisson regression models were used to estimate the interaction effects between sex and age. RESULTS: The sex-age-specific incidence rates of Grade 1, Grade 2, and Grade 3 second primary colorectal cancer (SPCRC) increased gradually with age, especially in females. There was a significant interaction effect between sex and age on the risk of Grade 3 second primary colon cancer. CONCLUSION: Decrease in female hormone level since menopausal age may increase the risk of a second primary colon cancer, especially a cancer with poorer differentiation.
Authors: Viktor Komlósi; Erika Hitre; Eva Pap; Vilmos Adleff; Andrea Réti; Eva Székely; Anna Bíró; Péter Rudnai; Bernadette Schoket; Judit Müller; Béla Tóth; Szabolcs Ottó; Miklós Kásler; Judit Kralovánszky; Barna Budai Journal: BMC Cancer Date: 2010-10-04 Impact factor: 4.430