| Literature DB >> 17603504 |
Bela Novak1, John J Tyson, Bela Gyorffy, Attila Csikasz-Nagy.
Abstract
The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.Mesh：
Substances：
Year: 2007 PMID： 17603504 DOI： 10.1038/ncb0707-724
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824