Literature DB >> 17602586

Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.

Elmi N Zainuddin1, Renate Mentel, Victor Wray, Rolf Jansen, Manfred Nimtz, Michael Lalk, Sabine Mundt.   

Abstract

Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.

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Year:  2007        PMID： 17602586     DOI： 10.1021/np060303s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  15 in total

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