Literature DB >> 17600707

Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Lori Sutin1, Sören Andersson, Lars Bergquist, Victor M Castro, Eva Danielsson, Stephen James, Martin Henriksson, Lars Johansson, Christina Kaiser, Katarina Flyrén, Meredith Williams.   

Abstract

2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.

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Year:  2007        PMID： 17600707     DOI： 10.1016/j.bmcl.2007.06.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination.

Authors:  James R Marshall; Peiyuan Yao; Sarah L Montgomery; James D Finnigan; Thomas W Thorpe; Ryan B Palmer; Juan Mangas-Sanchez; Richard A M Duncan; Rachel S Heath; Kirsty M Graham; Darren J Cook; Simon J Charnock; Nicholas J Turner
Journal:  Nat Chem       Date:  2020-12-30       Impact factor: 24.427

2.  Enantioselective hydrosilylation of unsaturated carbon-heteroatom bonds (C[double bond, length as m-dash]N, C[double bond, length as m-dash]O) catalyzed by [Ru-S] complexes: a theoretical study.

Authors:  Miao-Miao Zhou; Guanghui Chen; Li Dang
Journal:  RSC Adv       Date:  2020-03-04       Impact factor: 4.036

3.  Multi-enzyme pyruvate removal system to enhance (R)-selective reductive amination of ketones.

Authors:  Jinhua Zhang; Yanshu Zhao; Chao Li; Hao Song
Journal:  RSC Adv       Date:  2020-08-05       Impact factor: 4.036

Review 4.  Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis.

Authors:  Grzegorz Mlostoń; Emilia Obijalska; Heinz Heimgartner
Journal:  J Fluor Chem       Date:  2010-06-04       Impact factor: 2.050
  4 in total

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