Literature DB >> 17594013

Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation.

Kerry Wilson1, Peter Molnar, James Hickman.   

Abstract

We have developed a biological micro-electromechanical system (Bio-MEMS) device consisting of surface-modified microfabricated silicon cantilevers and an AFM detection apparatus for the study of cultured myotubes. With this system we are able to selectively stimulate the myotubes as well as report on a variety of physiological properties of the myotubes in real time and in a high-throughput manner. This system will serve as the foundation for future work integrating multiple tissue types for the creation of Bio-MEMS analogues of complex tissues and biological circuits.

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Year:  2007        PMID： 17594013     DOI： 10.1039/b617939h

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  19 in total

1.  Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.

Authors:  Xiufang Guo; Jennifer E Ayala; Mercedes Gonzalez; Maria Stancescu; Stephen Lambert; James J Hickman
Journal:  Biomaterials       Date:  2012-05-15       Impact factor: 12.479

2.  Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based bio-microelectromechanical systems device.

Authors:  K L Pirozzi; C J Long; C W McAleer; A S T Smith; J J Hickman
Journal:  Appl Phys Lett       Date:  2013-08-20       Impact factor: 3.791

3.  'Living cantilever arrays' for characterization of mass of single live cells in fluids.

Authors:  Kidong Park; Jaesung Jang; Daniel Irimia; Jennifer Sturgis; James Lee; J Paul Robinson; Mehmet Toner; Rashid Bashir
Journal:  Lab Chip       Date:  2008-06-11       Impact factor: 6.799

4.  A phenotypic in vitro model for the main determinants of human whole heart function.

Authors:  Maria Stancescu; Peter Molnar; Christopher W McAleer; William McLamb; Christopher J Long; Carlota Oleaga; Jean-Matthieu Prot; James J Hickman
Journal:  Biomaterials       Date:  2015-05-14       Impact factor: 12.479

5.  Mechanistic investigation of adult myotube response to exercise and drug treatment in vitro using a multiplexed functional assay system.

Authors:  C W McAleer; A S T Smith; S Najjar; K Pirozzi; C J Long; J J Hickman
Journal:  J Appl Physiol (1985)       Date:  2014-10-09

6.  Skeletal myotube integration with planar microelectrode arrays in vitro for spatially selective recording and stimulation: a comparison of neuronal and myotube extracellular action potentials.

Authors:  Christopher G Langhammer; Melinda K Kutzing; Vincent Luo; Jeffrey D Zahn; Bonnie L Firestein
Journal:  Biotechnol Prog       Date:  2011-05-13

Review 7.  Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.

Authors:  Ying I Wang; Carlos Carmona; James J Hickman; Michael L Shuler
Journal:  Adv Healthc Mater       Date:  2017-12-04       Impact factor: 9.933

8.  Direct patterning of coplanar polyethylene glycol alkylsilane monolayers by deep-ultraviolet photolithography as a general method for high fidelity, long-term cell patterning and culture.

Authors:  Kerry Wilson; Maria Stancescu; Mainak Das; John Rumsey; James Hickman
Journal:  J Vac Sci Technol B Nanotechnol Microelectron       Date:  2011-03-10

9.  Measurement of contractile stress generated by cultured rat muscle on silicon cantilevers for toxin detection and muscle performance enhancement.

Authors:  Kerry Wilson; Mainak Das; Kathryn J Wahl; Richard J Colton; James Hickman
Journal:  PLoS One       Date:  2010-06-10       Impact factor: 3.240

10.  Skeletal muscle tissue engineering: a maturation model promoting long-term survival of myotubes, structural development of the excitation-contraction coupling apparatus and neonatal myosin heavy chain expression.

Authors:  Mainak Das; John W Rumsey; Neelima Bhargava; Maria Stancescu; James J Hickman
Journal:  Biomaterials       Date:  2009-07-22       Impact factor: 12.479
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