OBJECTIVES: Our aim was to assess the oxidative stress and ameliorative effect of L-glutamine in serum, neutrophils, and lymphocytes of oral cancer patients by measuring the levels of malondialdehyde (MDA) and antioxidants. MATERIALS AND METHODS: This study has been conducted on serum and specific blood cells in adult, male oral cancer patients (stage III-6, stage IV-42) and normal subjects of an equal number of age and sex-matched disease-free healthy subjects. The levels of lipid peroxidation and antioxidant enzymes were assayed using spectrophotometric methods. RESULTS: MDA levels were elevated, and antioxidant enzyme status was decreased significantly in all groups of cancer patients simultaneously, but after supplementation of "glutammune" (66.66% L-glutamine), oxidative stress has been alleviated to some extent; especially, it has repaired the glutathione cascade system. CONCLUSION: We conclude that oxidative stress is due to the enhanced lipid peroxidation and decrease in antioxidant enzymes, and it can be restored with dietary supplementation of L-glutamine related drug.
OBJECTIVES: Our aim was to assess the oxidative stress and ameliorative effect of L-glutamine in serum, neutrophils, and lymphocytes of oral cancerpatients by measuring the levels of malondialdehyde (MDA) and antioxidants. MATERIALS AND METHODS: This study has been conducted on serum and specific blood cells in adult, male oral cancerpatients (stage III-6, stage IV-42) and normal subjects of an equal number of age and sex-matched disease-free healthy subjects. The levels of lipid peroxidation and antioxidant enzymes were assayed using spectrophotometric methods. RESULTS: MDA levels were elevated, and antioxidant enzyme status was decreased significantly in all groups of cancerpatients simultaneously, but after supplementation of "glutammune" (66.66% L-glutamine), oxidative stress has been alleviated to some extent; especially, it has repaired the glutathione cascade system. CONCLUSION: We conclude that oxidative stress is due to the enhanced lipid peroxidation and decrease in antioxidant enzymes, and it can be restored with dietary supplementation of L-glutamine related drug.
Authors: Giovanni Mantovani; Antonio Macciò; Clelia Madeddu; Loredana Mura; Giulia Gramignano; Maria Rita Lusso; Carlo Mulas; Maria Caterina Mudu; Viviana Murgia; Paolo Camboni; Elena Massa; Luca Ferreli; Paolo Contu; Augusto Rinaldi; Enrico Sanjust; Davide Atzei; Bernhard Elsener Journal: Int J Cancer Date: 2002-03-01 Impact factor: 7.396
Authors: Gerdien C Melis; Nathalie ter Wengel; Petra G Boelens; Paul A M van Leeuwen Journal: Curr Opin Clin Nutr Metab Care Date: 2004-01 Impact factor: 4.294
Authors: Abraham Z Reznick; Ifat Klein; Jason P Eiserich; Carroll E Cross; Rafael M Nagler Journal: Free Radic Biol Med Date: 2003-02-01 Impact factor: 7.376