Literature DB >> 17593029

Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia.

Ludger Sellmann1, Stefan Gesk, Christoph Walter, Matthias Ritgen, Lana Harder, José I Martín-Subero, Roland Schroers, Dörte Siemer, Holger Nückel, Martin J S Dyer, Ulrich Dührsen, Reiner Siebert, Jan Dürig, Ralf Küppers.   

Abstract

The occurrence of trisomy 19 was investigated in 705 cases of B-chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1.6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B-CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells.

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Year:  2007        PMID： 17593029     DOI： 10.1111/j.1365-2141.2007.06636.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  13 in total

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Authors:  Lina Shao; Sung-Hae L Kang; Jian Li; Patricia Hixson; Jesalyn Taylor; Svetlana A Yatsenko; Chad A Shaw; Aleksandar Milosavljevic; Chung-Che Chang; Sau Wai Cheung; Ankita Patel
Journal:  J Mol Diagn       Date:  2010-08-19       Impact factor: 5.568

2.  Whole-genome scanning by array comparative genomic hybridization as a clinical tool for risk assessment in chronic lymphocytic leukemia.

Authors:  Shelly R Gunn; Mansoor S Mohammed; Mercedes E Gorre; Philip D Cotter; Jaeweon Kim; David W Bahler; Sergey N Preobrazhensky; Russell A Higgins; Aswani R Bolla; Sahar H Ismail; Daphne de Jong; Eric Eldering; Marinus H J van Oers; Clemens H M Mellink; Michael J Keating; Ellen J Schlette; Lynne V Abruzzo; Ryan S Robetorye
Journal:  J Mol Diagn       Date:  2008-08-07       Impact factor: 5.568

Review 3.  Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolution.

Authors:  Lesley-Ann Sutton; Richard Rosenquist
Journal:  Haematologica       Date:  2015-01       Impact factor: 9.941

4.  Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference.

Authors:  Panagiotis Baliakas; Anna Puiggros; Aliki Xochelli; Lesley-Ann Sutton; Florence Nguyen-Khac; Anne Gardiner; Karla Plevova; Eva Minga; Anastasia Hadzidimitriou; Renata Walewska; Helen McCarthy; Margarita Ortega; Rosa Collado; Teresa González; Isabel Granada; Elisa Luño; Jana Kotašková; Theodoros Moysiadis; Zadie Davis; Niki Stavroyianni; Achilles Anagnostopoulos; Jonathan C Strefford; Sarka Pospisilova; Frederic Davi; Anastasia Athanasiadou; Richard Rosenquist; David Oscier; Blanca Espinet; Kostas Stamatopoulos
Journal:  Haematologica       Date:  2016-04-21       Impact factor: 9.941

5.  Second cancers and Richter transformation are the leading causes of death in patients with trisomy 12 chronic lymphocytic leukemia.

Authors:  Paolo Strati; Lynne V Abruzzo; William G Wierda; Susan O'Brien; Alessandra Ferrajoli; Michael J Keating
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2015-02-11

6.  Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact.

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Journal:  Blood       Date:  2019-01-02       Impact factor: 22.113

7.  Detection, analysis and clinical validation of chromosomal aberrations by multiplex ligation-dependent probe amplification in chronic leukemia.

Authors:  Adam Abdool; Amber C Donahue; Jay G Wohlgemuth; Chen-Hsiung Yeh
Journal:  PLoS One       Date:  2010-10-25       Impact factor: 3.240

Review 8.  Prognostic Factors in the Era of Targeted Therapies in CLL.

Authors:  Prajwal Boddu; Alessandra Ferrajoli
Journal:  Curr Hematol Malig Rep       Date:  2018-04       Impact factor: 3.952

9.  Chronic Lymphocytic Leukemia with Divergent Richter's Transformation into a Clonally Related Classical Hodgkin's and Plasmablastic Lymphoma: A Case Report.

Authors:  Gorana Gasljevic; Mateja Grat; Veronika Kloboves Prevodnik; Biljana Grcar Kuzmanov; Barbara Gazic; Luca Lovrecic; Helena Podgornik
Journal:  Case Rep Oncol       Date:  2020-02-13

10.  Evaluation of chronic lymphocytic leukemia by oligonucleotide-based microarray analysis uncovers novel aberrations not detected by FISH or cytogenetic analysis.

Authors:  Kathryn A Kolquist; Roger A Schultz; Marilyn L Slovak; Lisa D McDaniel; Theresa C Brown; Raymond R Tubbs; James R Cook; Karl S Theil; Victoria Cawich; Caitlin Valentin; Sara Minier; Nicholas J Neill; Steve Byerly; S Annie Morton; Trilochan Sahoo; Blake C Ballif; Lisa G Shaffer
Journal:  Mol Cytogenet       Date:  2011-11-16       Impact factor: 2.009
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