AIM: To evaluate the possible link between the severity of periodontal disease and pre-eclampsia and to correlate this link to clinical periodontal parameters and interleukin (IL)-1beta, tumour necrosis factor-alpha (TNF-alpha), and prostaglandins (PGE(2)) levels in both gingival crevicular fluid (GCF) and serum. MATERIAL AND METHODS: Fifty-nine pregnant women (20 mild pre-eclampsia, 18 severe pre-eclampsia, and 21 healthy pregnant women) were included in the study. Dental and periodontal recordings as well as GCF and blood samples were obtained within 48 h preceding delivery. RESULTS: The results of multivariate logistic regression showed a highly significant association between mild to severe pre-eclampsia and severe periodontal disease (p<0.001). After adjusting for potential confounders (smoking, body weight, socioeconomic status, education level, and age), severe pre-eclamptic women were 3.78 (1.77-12.74) times more likely to present severe periodontal disease than normotensive pregnant women. This odds ratio (OR) was 2.43 (1.13-8.19) for mild pre-eclamptic women. IL-1beta, TNF-alpha, and PGE(2) levels in both serum and GCF were also significantly higher in the pre-eclamptic groups than the normotensive women. CONCLUSIONS: These results indicate that the presence and severity of periodontal disease seems to increase the risk for not only the occurrence but also the severity of pre-eclampsia in pregnant women.
AIM: To evaluate the possible link between the severity of periodontal disease and pre-eclampsia and to correlate this link to clinical periodontal parameters and interleukin (IL)-1beta, tumour necrosis factor-alpha (TNF-alpha), and prostaglandins (PGE(2)) levels in both gingival crevicular fluid (GCF) and serum. MATERIAL AND METHODS: Fifty-nine pregnant women (20 mild pre-eclampsia, 18 severe pre-eclampsia, and 21 healthy pregnant women) were included in the study. Dental and periodontal recordings as well as GCF and blood samples were obtained within 48 h preceding delivery. RESULTS: The results of multivariate logistic regression showed a highly significant association between mild to severe pre-eclampsia and severe periodontal disease (p<0.001). After adjusting for potential confounders (smoking, body weight, socioeconomic status, education level, and age), severe pre-eclamptic women were 3.78 (1.77-12.74) times more likely to present severe periodontal disease than normotensive pregnant women. This odds ratio (OR) was 2.43 (1.13-8.19) for mild pre-eclamptic women. IL-1beta, TNF-alpha, and PGE(2) levels in both serum and GCF were also significantly higher in the pre-eclamptic groups than the normotensive women. CONCLUSIONS: These results indicate that the presence and severity of periodontal disease seems to increase the risk for not only the occurrence but also the severity of pre-eclampsia in pregnant women.
Authors: Pascale F M Stadelmann; Sigrun Eick; Giovanni E Salvi; Daniel Surbek; Stefan Mohr; Walter Bürgin; Christoph A Ramseier; Anton Sculean Journal: Clin Oral Investig Date: 2014-11-26 Impact factor: 3.573
Authors: Pascale Stadelmann; Regina Alessandri; Sigrun Eick; Giovanni E Salvi; Daniel Surbek; Anton Sculean Journal: Clin Oral Investig Date: 2013-03-07 Impact factor: 3.573
Authors: Nawel Taghzouti; Xu Xiong; Mervyn Gornitsky; Fatiha Chandad; René Voyer; Guy Gagnon; Line Leduc; Hairong Xu; Togas Tulandi; Bin Wei; Julie Sénécal; Ana M Velly; Mohammad H Salah; William D Fraser Journal: J Periodontol Date: 2011-12-22 Impact factor: 6.993
Authors: Francisco Mesa; Elena Pozo; Francisco O'Valle; Alberto Puertas; Antonio Magan-Fernandez; Eva Rosel; Manuel Bravo Journal: Clin Oral Investig Date: 2015-08-07 Impact factor: 3.573