| Literature DB >> 17588748 |
Scott B Hoyt1, Clare London, David Gorin, Matthew J Wyvratt, Michael H Fisher, Catherine Abbadie, John P Felix, Maria L Garcia, Xiaohua Li, Kathryn A Lyons, Erin McGowan, D Euan MacIntyre, William J Martin, Birgit T Priest, Amy Ritter, McHardy M Smith, Vivien A Warren, Brande S Williams, Gregory J Kaczorowski, William H Parsons.
Abstract
A series of benzodiazepines and benzazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of the benzazepinone series, compound 47, displayed potent, state-dependent block of hNa(v)1.7, and was orally efficacious in a rat model of neuropathic pain.Entities:
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Year: 2007 PMID： 17588748 DOI： 10.1016/j.bmcl.2007.05.076
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823