Literature DB >> 19789071

Sodium channel blockers for the treatment of neuropathic pain.

Anindya Bhattacharya1, Alan D Wickenden, Sandra R Chaplan.   

Abstract

Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the use of sodium channel blockers, describe the current status of sodium channel drug discovery, highlight the challenges and hurdles to attain sodium channel subtype selectivity, and review the potential usefulness of selective sodium channel blockers in neuropathic pain.

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Year:  2009        PMID： 19789071      PMCID： PMC5084288          DOI： 10.1016/j.nurt.2009.08.001

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  202 in total

1.  Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.

Authors:  Birgit T Priest; Beth A Murphy; Jill A Lindia; Carmen Diaz; Catherine Abbadie; Amy M Ritter; Paul Liberator; Leslie M Iyer; Shera F Kash; Martin G Kohler; Gregory J Kaczorowski; D Euan MacIntyre; William J Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-17       Impact factor: 11.205

2.  The response of neuropathic pain and pain in complex regional pain syndrome I to carbamazepine and sustained-release morphine in patients pretreated with spinal cord stimulation: a double-blinded randomized study.

Authors:  H Harke; P Gretenkort; H U Ladleif; S Rahman; O Harke
Journal:  Anesth Analg       Date:  2001-02       Impact factor: 5.108

3.  A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.

Authors:  J F Wernicke; Y L Pritchett; D N D'Souza; A Waninger; P Tran; S Iyengar; J Raskin
Journal:  Neurology       Date:  2006-10-24       Impact factor: 9.910

4.  Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

Authors:  Theodore R Cummins; Sulayman D Dib-Hajj; Stephen G Waxman
Journal:  J Neurosci       Date:  2004-09-22       Impact factor: 6.167

5.  Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat.

Authors:  Feng Guo; Na Yu; Ji-Qun Cai; Tim Quinn; Zhi-Hong Zong; Yan-Jun Zeng; Li-Ying Hao
Journal:  Brain Res Bull       Date:  2007-11-08       Impact factor: 4.077

6.  Efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled trial, N01C3.

Authors:  Ravi D Rao; Patrick J Flynn; Jeff A Sloan; Gilbert Y Wong; Paul Novotny; David B Johnson; Howard M Gross; Samer I Renno; Mohammed Nashawaty; Charles L Loprinzi
Journal:  Cancer       Date:  2008-06-15       Impact factor: 6.860

7.  The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.

Authors:  Adam C Errington; Thomas Stöhr; Cara Heers; George Lees
Journal:  Mol Pharmacol       Date:  2007-10-16       Impact factor: 4.436

8.  Dercum's disease (adiposis dolorosa). Treatment of the severe pain with intravenous lidocaine.

Authors:  Palle Petersen; Jens Kastrup
Journal:  Pain       Date:  1987-01       Impact factor: 6.961

9.  Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures.

Authors:  Tateki Fujiwara; Takashi Sugawara; Emi Mazaki-Miyazaki; Yukitoshi Takahashi; Katsuyuki Fukushima; Masako Watanabe; Keita Hara; Tateki Morikawa; Kazuichi Yagi; Kazuhiro Yamakawa; Yushi Inoue
Journal:  Brain       Date:  2003-03       Impact factor: 13.501

10.  ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

Authors:  William A Schmalhofer; Jeffrey Calhoun; Rachel Burrows; Timothy Bailey; Martin G Kohler; Adam B Weinglass; Gregory J Kaczorowski; Maria L Garcia; Martin Koltzenburg; Birgit T Priest
Journal:  Mol Pharmacol       Date:  2008-08-26       Impact factor: 4.436
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  19 in total

Review 1.  Targeting voltage-gated sodium channels for treatment for chronic visceral pain.

Authors:  Fei-Hu Qi; You-Lang Zhou; Guang-Yin Xu
Journal:  World J Gastroenterol       Date:  2011-05-21       Impact factor: 5.742

Review 2.  The discovery and development of analgesics: new mechanisms, new modalities.

Authors:  Gillian Burgess; Dic Williams
Journal:  J Clin Invest       Date:  2010-11-01       Impact factor: 14.808

3.  Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.

Authors:  David Shaya; Felix Findeisen; Fayal Abderemane-Ali; Cristina Arrigoni; Stephanie Wong; Shailika Reddy Nurva; Gildas Loussouarn; Daniel L Minor
Journal:  J Mol Biol       Date:  2013-10-10       Impact factor: 5.469

4.  Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.

Authors:  David Shaya; Mohamed Kreir; Rebecca A Robbins; Stephanie Wong; Justus Hammon; Andrea Brüggemann; Daniel L Minor
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-11       Impact factor: 11.205

Review 5.  Pharmacological Management of Chronic Pelvic Pain in Women.

Authors:  Erin T Carey; Sara R Till; Sawsan As-Sanie
Journal:  Drugs       Date:  2017-03       Impact factor: 9.546

6.  Endothelin-1 Decreases Excitability of the Dorsal Root Ganglion Neurons via ETB Receptor.

Authors:  Nandkishor K Mule; Jitendra N Singh; Kunal U Shah; Anil Gulati; Shyam S Sharma
Journal:  Mol Neurobiol       Date:  2017-06-16       Impact factor: 5.590

7.  Differences in local anaesthetic and antiepileptic binding in the inactivated state of human sodium channel Nav1.4.

Authors:  Amanda Buyan; Aidan A Whitfield; Ben Corry
Journal:  Biophys J       Date:  2021-11-11       Impact factor: 4.033

8.  In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach.

Authors:  Ivana Kalezic; Lei Luo; Per-Eric Lund; Anders B Eriksson; Tjerk Bueters; Sandra A G Visser
Journal:  Pharm Res       Date:  2013-02-01       Impact factor: 4.200

9.  Evaluation of the effects of novel nafimidone derivatives on thermal hypoalgesia in mice with diabetic neuropathy.

Authors:  Suat Kamışlı; Arzu Karakurt; Ayşe B Uyumlu; Basri Satılmış; Abdullah Alagöz; Metin F Genç; Kadir Batcıoğlu
Journal:  Balkan Med J       Date:  2013-03-01       Impact factor: 2.021

Review 10.  Tetrodotoxin (TTX) as a therapeutic agent for pain.

Authors:  Francisco Rafael Nieto; Enrique José Cobos; Miguel Ángel Tejada; Cristina Sánchez-Fernández; Rafael González-Cano; Cruz Miguel Cendán
Journal:  Mar Drugs       Date:  2012-01-31       Impact factor: 6.085
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