OBJECTIVE: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL. METHODS: Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk. RESULTS: A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8). CONCLUSIONS: We infer that some childhood and immune-related factors may alter NHL risk.
OBJECTIVE: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL. METHODS: Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk. RESULTS: A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8). CONCLUSIONS: We infer that some childhood and immune-related factors may alter NHL risk.
Authors: Nikolaus Becker; Michael O Falster; Claire M Vajdic; Silvia de Sanjose; Otoniel Martínez-Maza; Paige M Bracci; Mads Melbye; Karin Ekström Smedby; Eric A Engels; Jennifer Turner; Paolo Vineis; Adele Seniori Costantini; Elizabeth A Holly; John J Spinelli; Carlo La Vecchia; Tongzhang Zheng; Brian C-H Chiu; Maurizio Montella; Pierluigi Cocco; Marc Maynadié; Lenka Foretova; Anthony Staines; Paul Brennan; Scott Davis; Richard Severson; James R Cerhan; Elizabeth C Breen; Brenda Birmann; Wendy Cozen; Andrew E Grulich; Robert Newton Journal: Int J Cancer Date: 2012-08-12 Impact factor: 7.396
Authors: Andrew E Grulich; Claire M Vajdic; Michael O Falster; Eleanor Kane; Karin Ekstrom Smedby; Paige M Bracci; Silvia de Sanjose; Nikolaus Becker; Jenny Turner; Otoniel Martinez-Maza; Mads Melbye; Eric A Engels; Paolo Vineis; Adele Seniori Costantini; Elizabeth A Holly; John J Spinelli; Carlo La Vecchia; Tongzhang Zheng; Brian C H Chiu; Silvia Franceschi; Pierluigi Cocco; Marc Maynadié; Lenka Foretova; Anthony Staines; Paul Brennan; Scott Davis; Richard K Severson; James R Cerhan; Elizabeth C Breen; Brenda Birmann; Wendy Cozen Journal: Am J Epidemiol Date: 2010-08-18 Impact factor: 4.897
Authors: Jun Wang; Thomas M Mack; Ann S Hamilton; Amie E Hwang; Bharat N Nathwani; Kamil Masood; Laura H Buchanan; Leslie Bernstein; Dennis M Deapen; Otoniel Martínez-Maza; Wendy Cozen Journal: Am J Epidemiol Date: 2015-08-12 Impact factor: 4.897
Authors: Jun Wang; Wendy Cozen; Peter S Thorne; Kiros Berhane; James R Cerhan; Patricia Hartge; Mary H Ward; Anneclaire J De Roos; Richard K Severson; Lindsay M Morton; Leslie Bernstein; Martha S Linet; Joanne S Colt Journal: Cancer Causes Control Date: 2013-01-01 Impact factor: 2.506
Authors: Lindsay M Morton; Sophia S Wang; Wendy Cozen; Martha S Linet; Nilanjan Chatterjee; Scott Davis; Richard K Severson; Joanne S Colt; Mohammad A Vasef; Nathaniel Rothman; Aaron Blair; Leslie Bernstein; Amanda J Cross; Anneclaire J De Roos; Eric A Engels; David W Hein; Deirdre A Hill; Linda E Kelemen; Unhee Lim; Charles F Lynch; Maryjean Schenk; Sholom Wacholder; Mary H Ward; Shelia Hoar Zahm; Stephen J Chanock; James R Cerhan; Patricia Hartge Journal: Blood Date: 2008-09-16 Impact factor: 22.113